{"id":"9e94ce18-a5df-5815-a977-2d5f4d0dad6c","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-infant-regurgitation-response","predicate":"increased_reported_regurgitation_improvement","statement":"Regurgitation improvement was reported in 69% versus 29% (P=0.003).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"3a8b000e-4148-5442-ab90-a31de1f3918c","mechanism_event_label":"Feeding-related symptoms also improved more often in the intervention group.","subject":{"id":"5cbf4388-4e34-5798-880a-ca463dfd90cf","slug":"hydroxocobalamin","display_name":"Hydroxocobalamin","entity_type_key":"small_molecule"},"object":{"id":"b6e7c28e-191a-5634-a99f-3991560cf240","slug":"infant-regurgitation-improvement","display_name":"Reported infant regurgitation improvement","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3a8b000e-4148-5442-ab90-a31de1f3918c","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-infant-regurgitation-response-event","event_type":"observed_intervention","label":"Feeding-related symptoms also improved more often in the intervention group.","description":"Regurgitation improvement was reported in 69% versus 29% (P=0.003).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5cbf4388-4e34-5798-880a-ca463dfd90cf","slug":"hydroxocobalamin","display_name":"Hydroxocobalamin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b6e7c28e-191a-5634-a99f-3991560cf240","slug":"infant-regurgitation-improvement","display_name":"Reported infant regurgitation improvement","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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unverified.","entity":null}],"evidence":[{"id":"51f4847b-98d5-5bc4-8515-d58ea8e2ea2f","evidence_kind":"source_excerpt","locator":"Lines 1758-1768","start_line":1758,"end_line":1768,"excerpt":"### b12-infant-regurgitation-response\nRegurgitation improvement was reported in 69% versus 29% (P=0.003).\nCondition category: biomarker_context\nnutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Feeding-related symptoms also improved more often in the intervention group.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Double-blind randomized trial: 79 referred infants younger than eight months with plasma total homocysteine at least 6.5 micromol/L, from 105 assessed.\nlimitations: Parental symptom report in a selected short trial; does not identify the molecular gut mechanism.\nexposure: One 400-microgram intramuscular hydroxocobalamin injection (42 infants) versus sham injection (37); one-month follow-up.\n[b12-torsvik2013] Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study (2013). https://pubmed.ncbi.nlm.nih.gov/24025626/ DOI: 10.3945/ajcn.113.061549","model_system":"Double-blind randomized trial: 79 referred infants younger than eight months with plasma total homocysteine at least 6.5 micromol/L, from 105 assessed.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b12-torsvik2013] Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study (2013). https://pubmed.ncbi.nlm.nih.gov/24025626/ DOI: 10.3945/ajcn.113.061549","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73145023-2982-5848-aff2-8d8875d6b9c5","stable_key":"import-7fc92b9e-9cbf-556e-8719-6b5244625250","title":"Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ad5b3a51d36e856aa7fdfd1cc23f690b094689bad87d28e1a621a54675a01c92","revision_id":"118bd616-0c13-549f-bfeb-bc439715b89c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}