Component
Infant neurodevelopmental impairment
Infant neurodevelopmental impairment
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
During follow-up, seven children had cognitive and motor impairment, and six developed severe epilepsy after the initial deficiency episode.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_location
- Abstract Results
- evidence_span
- six developed severe epilepsy
- experimental_model
- Case series of 11 severely affected children from the Israeli thiamine-deficient formula outbreak, with longitudinal follow-up of eight initial survivors.
- exposure
- Consumption of a formula with thiamine below the assay detection limit
- limitations
- Selected severe survivor cohort without an unexposed comparison; not evidence that mild or asymptomatic low intake has the same prognosis.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Homo sapiens
- plain_language
- Correction of the nutritional exposure did not guarantee recovery from established neurological injury.
- primary_references
- [mimouni-bloch-2014-infant-followup] Thiamine deficiency in infancy: long-term follow-up. (2014). https://pubmed.ncbi.nlm.nih.gov/25160536/ DOI: 10.1016/j.pediatrneurol.2014.05.010
- tissue_or_cell_type
- Longitudinal neurodevelopmental assessment
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1521–1533
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Case series of 11 severely affected children from the Israeli thiamine-deficient formula outbreak, with longitudinal follow-up of eight initial survivors. · source_derived_draft · unverified_draft
### thiamine-def-infant-persistent-neurodevelopmental-sequelae During follow-up, seven children had cognitive and motor impairment, and six developed severe epilepsy after the initial deficiency episode. Condition category: nutrient_deficiency nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Correction of the nutritional exposure did not guarantee recovery from established neurological injury. organism: Homo sapiens tissue_or_cell_type: Longitudinal neurodevelopmental assessment experimental_model: Case series of 11 severely affected children from the Israeli thiamine-deficient formula outbreak, with longitudinal follow-up of eight initial survivors. limitations: Selected severe survivor cohort without an unexposed comparison; not evidence that mild or asymptomatic low intake has the same prognosis. evidence_location: Abstract Results evidence_span: six developed severe epilepsy exposure: Consumption of a formula with thiamine below the assay detection limit [mimouni-bloch-2014-infant-followup] Thiamine deficiency in infancy: long-term follow-up. (2014). https://pubmed.ncbi.nlm.nih.gov/25160536/ DOI: 10.1016/j.pediatrneurol.2014.05.010
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.