{"id":"632daca0-8845-515d-a21e-f60034568dc4","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-infant-persistent-neurodevelopmental-sequelae","predicate":"severe-deficiency-associated-with","statement":"During follow-up, seven children had cognitive and motor impairment, and six developed severe epilepsy after the initial deficiency episode.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"15e26a76-c739-5eae-acef-61112360a228","mechanism_event_label":"Correction of the nutritional exposure did not guarantee recovery from established neurological injury.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"a9253b19-2911-5930-800e-f8ce6491930a","slug":"infant-neurodevelopmental-impairment","display_name":"Infant neurodevelopmental impairment","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"15e26a76-c739-5eae-acef-61112360a228","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-infant-persistent-neurodevelopmental-sequelae-event","event_type":"observed_intervention","label":"Correction of the nutritional exposure did not guarantee recovery from established neurological injury.","description":"During follow-up, seven children had cognitive and motor impairment, and six developed severe epilepsy after the initial deficiency episode.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a9253b19-2911-5930-800e-f8ce6491930a","slug":"infant-neurodevelopmental-impairment","display_name":"Infant neurodevelopmental impairment","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_location","value_text":"Abstract Results","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"six developed severe epilepsy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Case series of 11 severely affected children from the Israeli thiamine-deficient formula outbreak, with longitudinal follow-up of eight initial survivors.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Consumption of a formula with thiamine below the assay detection limit","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Selected severe survivor cohort without an unexposed comparison; not evidence that mild or asymptomatic low intake has the same prognosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Correction of the nutritional exposure did not guarantee recovery from established neurological injury.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mimouni-bloch-2014-infant-followup] Thiamine deficiency in infancy: long-term follow-up. (2014). https://pubmed.ncbi.nlm.nih.gov/25160536/ DOI: 10.1016/j.pediatrneurol.2014.05.010","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Longitudinal neurodevelopmental assessment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"362ecd37-e948-5def-b159-6b53bf6eab79","evidence_kind":"source_excerpt","locator":"Lines 1521-1533","start_line":1521,"end_line":1533,"excerpt":"### thiamine-def-infant-persistent-neurodevelopmental-sequelae\nDuring follow-up, seven children had cognitive and motor impairment, and six developed severe epilepsy after the initial deficiency episode.\nCondition category: nutrient_deficiency\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Correction of the nutritional exposure did not guarantee recovery from established neurological injury.\norganism: Homo sapiens\ntissue_or_cell_type: Longitudinal neurodevelopmental assessment\nexperimental_model: Case series of 11 severely affected children from the Israeli thiamine-deficient formula outbreak, with longitudinal follow-up of eight initial survivors.\nlimitations: Selected severe survivor cohort without an unexposed comparison; not evidence that mild or asymptomatic low intake has the same prognosis.\nevidence_location: Abstract Results\nevidence_span: six developed severe epilepsy\nexposure: Consumption of a formula with thiamine below the assay detection limit\n[mimouni-bloch-2014-infant-followup] Thiamine deficiency in infancy: long-term follow-up. 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