Component
Infant language-development score in the 2012 PC supplementation trial
Infant language-development score in the 2012 PC supplementation trial. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The PC supplementation and placebo groups did not differ significantly in language development at the reported infant follow-up assessments.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/choline-research/23134891.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c639fd65120036e4dcce961161222da3632034d148564db3c98bcc36a788084e", "start_char": 0, "end_char": 1592, "text_sha256": "c639fd65120036e4dcce961161222da3632034d148564db3c98bcc36a788084e"}
- experimental_model
- Randomized double-blind placebo-controlled maternal PC supplementation
- exposure
- 750 mg choline/day delivered as PC, not 750 mg PC mass; weeks 18 through 90 days postpartum; background food choline about 360 mg/day
- limitations
- Dose identity checked in full-text intervention section. Different endpoints, timing and feeding control from the 2018 trial; a null result is not proof of no effect on every possible outcome.
- nutrient_topic
- Choline research collection; topical membership is not evidence of a direct dietary effect. · Choline
- organism
- Human
- plain_language
- This measured outcome did not improve significantly in the trial.
- primary_references
- [choline-p23134891] Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. (2012). https://pubmed.ncbi.nlm.nih.gov/23134891/ DOI: 10.3945/ajcn.112.037184
- tissue_or_cell_type
- 140 randomized women; 99 infants in follow-up
Choline: metabolism, signaling and nutrient connections (2026-09-17) · lines 1283–1294
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled maternal PC supplementation · source_derived_draft · unverified_draft
### choline-maternal-language-null The PC supplementation and placebo groups did not differ significantly in language development at the reported infant follow-up assessments. Condition category: normal nutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect. plain_language: This measured outcome did not improve significantly in the trial. organism: Human tissue_or_cell_type: 140 randomized women; 99 infants in follow-up experimental_model: Randomized double-blind placebo-controlled maternal PC supplementation limitations: Dose identity checked in full-text intervention section. Different endpoints, timing and feeding control from the 2018 trial; a null result is not proof of no effect on every possible outcome. exposure: 750 mg choline/day delivered as PC, not 750 mg PC mass; weeks 18 through 90 days postpartum; background food choline about 360 mg/day evidence_span: {"source_cache": "artifacts/choline-research/23134891.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c639fd65120036e4dcce961161222da3632034d148564db3c98bcc36a788084e", "start_char": 0, "end_char": 1592, "text_sha256": "c639fd65120036e4dcce961161222da3632034d148564db3c98bcc36a788084e"} [choline-p23134891] Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. (2012). https://pubmed.ncbi.nlm.nih.gov/23134891/ DOI: 10.3945/ajcn.112.037184
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.