Component
Tight junction proteins at the ileal epithelium
Tight junction proteins at the ileal epithelium. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Zinc deprivation caused epithelial barrier disruption in association with disassembly of tight junction proteins in Caco-2 monolayers, and minor zinc deprivation exaggerated the deleterious effect of alcohol on the epithelial barrier.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/alcohol-research/20167873.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12b4bf025e28831a9d613fd7d6b62275f573f8a8999efb73d763bb8e8059b15e", "start_char": 0, "end_char": 1542, "text_sha256": "12b4bf025e28831a9d613fd7d6b62275f573f8a8999efb73d763bb8e8059b15e"}
- experimental_model
- Pair-fed alcohol mice with regional permeability measurement and Caco-2 zinc deprivation
- exposure
- Four weeks of alcohol liquid diet; zinc deprivation in culture
- limitations
- The regional specificity and the separate zinc-deprivation arm are what make the nutrient claim interpretable. The exaggeration experiment is in cultured cells.
- nutrient_topic
- Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. · Ethanol
- organism
- Mouse and human cells
- plain_language
- Take zinc away and the seals between cells come apart, with or without alcohol.
- primary_references
- [alcohol-p20167873] The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. (2010). https://pubmed.ncbi.nlm.nih.gov/20167873/ DOI: 10.1152/ajpgi.00350.2009
- tissue_or_cell_type
- Ileum and Caco-2 monolayers
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21) · lines 774–785
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Pair-fed alcohol mice with regional permeability measurement and Caco-2 zinc deprivation · source_derived_draft · unverified_draft
### alcohol-zinc-tight-junctions Zinc deprivation caused epithelial barrier disruption in association with disassembly of tight junction proteins in Caco-2 monolayers, and minor zinc deprivation exaggerated the deleterious effect of alcohol on the epithelial barrier. Condition category: nutrient_deficiency nutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes. plain_language: Take zinc away and the seals between cells come apart, with or without alcohol. organism: Mouse and human cells tissue_or_cell_type: Ileum and Caco-2 monolayers experimental_model: Pair-fed alcohol mice with regional permeability measurement and Caco-2 zinc deprivation limitations: The regional specificity and the separate zinc-deprivation arm are what make the nutrient claim interpretable. The exaggeration experiment is in cultured cells. exposure: Four weeks of alcohol liquid diet; zinc deprivation in culture evidence_span: {"source_cache": "artifacts/alcohol-research/20167873.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "12b4bf025e28831a9d613fd7d6b62275f573f8a8999efb73d763bb8e8059b15e", "start_char": 0, "end_char": 1542, "text_sha256": "12b4bf025e28831a9d613fd7d6b62275f573f8a8999efb73d763bb8e8059b15e"} [alcohol-p20167873] The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. (2010). https://pubmed.ncbi.nlm.nih.gov/20167873/ DOI: 10.1152/ajpgi.00350.2009
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.