Component
Human umbilical vein endothelial cell proliferation
Human umbilical vein endothelial cell proliferation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
HUVEC proliferation decreased dose-dependently at 50-200 micromolar.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/nasunin-research/16076105.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5b1a82636d590c80ec052a338bd3ebf58a1094004238cfda2c404e8ee98f5ad2", "start_char": 0, "end_char": 785, "text_sha256": "5b1a82636d590c80ec052a338bd3ebf58a1094004238cfda2c404e8ee98f5ad2"}
- experimental_model
- Aortic-ring outgrowth and separate endothelial assays
- exposure
- Outgrowth suppression at concentrations above 10 micromolar; proliferation 50-200 micromolar
- limitations
- Ex vivo and cell endpoints do not establish cancer prevention or direct VEGF/VEGFR inhibition. Null migration and tube assays are distinct endpoints, not contradictions.
- nutrient_topic
- Nasunin research collection; topical membership is not evidence of a direct dietary effect. · Nasunin
- organism
- Rat aortic rings and human HUVEC cultures
- plain_language
- One component of vessel formation slowed.
- primary_references
- [nasunin-p16076105] Antiangiogenic activity of nasunin, an antioxidant anthocyanin, in eggplant peels. (2005). https://pubmed.ncbi.nlm.nih.gov/16076105/ DOI: 10.1021/jf050796r
- tissue_or_cell_type
- Microvessel formation, proliferation, migration and tubes
Nasunin: identity, redox chemistry and nutrient connections (2026-09-17) · lines 809–820
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Aortic-ring outgrowth and separate endothelial assays · source_derived_draft · unverified_draft
### nasunin-endothelial-proliferation HUVEC proliferation decreased dose-dependently at 50-200 micromolar. Condition category: normal nutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect. plain_language: One component of vessel formation slowed. organism: Rat aortic rings and human HUVEC cultures tissue_or_cell_type: Microvessel formation, proliferation, migration and tubes experimental_model: Aortic-ring outgrowth and separate endothelial assays limitations: Ex vivo and cell endpoints do not establish cancer prevention or direct VEGF/VEGFR inhibition. Null migration and tube assays are distinct endpoints, not contradictions. exposure: Outgrowth suppression at concentrations above 10 micromolar; proliferation 50-200 micromolar evidence_span: {"source_cache": "artifacts/nasunin-research/16076105.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "5b1a82636d590c80ec052a338bd3ebf58a1094004238cfda2c404e8ee98f5ad2", "start_char": 0, "end_char": 785, "text_sha256": "5b1a82636d590c80ec052a338bd3ebf58a1094004238cfda2c404e8ee98f5ad2"} [nasunin-p16076105] Antiangiogenic activity of nasunin, an antioxidant anthocyanin, in eggplant peels. (2005). https://pubmed.ncbi.nlm.nih.gov/16076105/ DOI: 10.1021/jf050796r
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.