Component
Whole-blood intracellular NAD measurement
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A five-day placebo-controlled trial of oral LNAD+ reported whole-blood intracellular NAD 53% higher versus placebo at day six; 60 adults were randomized and 50 entered the primary analysis.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Healthy adults aged 45–75; short phase 0/1b trial, NCT07336836, retrospectively registered.
- limitations
- Primary abstract only. Formulation-specific, no isotope-traced intact uptake, no inference about muscle or brain NAD; exclusions and assay details require full-report appraisal.
- nutrient_topic
- NAD+ collection; molecular form, preparation, species, exposure and manipulation remain explicit. · NAD+
- plain_language
- A particular oral formulation increased a blood-cell-associated NAD measure.
- primary_references
- Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42530810/ · DOI 10.1007/s11357-026-02399-1
- trigger_kind
- biomarker_context Imported condition classification; unverified.
NAD+: compartmental supply, consumption and cross-nutrient mechanisms (2026-09-19) · lines 308–314
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Healthy adults aged 45–75; short phase 0/1b trial, NCT07336836, retrospectively registered. · source_derived_draft · unverified_draft
## nad-plus-oral-formulation-blood A particular oral formulation increased a blood-cell-associated NAD measure. A five-day placebo-controlled trial of oral LNAD+ reported whole-blood intracellular NAD 53% higher versus placebo at day six; 60 adults were randomized and 50 entered the primary analysis. Model: Healthy adults aged 45–75; short phase 0/1b trial, NCT07336836, retrospectively registered. Limitations: Primary abstract only. Formulation-specific, no isotope-traced intact uptake, no inference about muscle or brain NAD; exclusions and assay details require full-report appraisal. Evidence access: Primary abstract Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42530810/ · DOI 10.1007/s11357-026-02399-1
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.