{"id":"a65f75d8-d401-5089-ae0a-ee4212c8d84b","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-oral-formulation-blood","predicate":"increases","statement":"A five-day placebo-controlled trial of oral LNAD+ reported whole-blood intracellular NAD 53% higher versus placebo at day six; 60 adults were randomized and 50 entered the primary analysis.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f691a0b4-4110-57cc-86d4-bcf017fe1389","mechanism_event_label":"A particular oral formulation increased a blood-cell-associated NAD measure.","subject":{"id":"9cf73903-df6e-575d-aec2-9a3c67e2054a","slug":"lnad-plus-formulation","display_name":"LathMized NAD+ formulation","entity_type_key":"chemical_species"},"object":{"id":"0abce882-a8cb-516b-b785-b98df59efc88","slug":"human-whole-blood-intracellular-nad","display_name":"Whole-blood intracellular NAD measurement","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f691a0b4-4110-57cc-86d4-bcf017fe1389","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-oral-formulation-blood-event","event_type":"observed_relationship","label":"A particular oral formulation increased a blood-cell-associated NAD measure.","description":"A five-day placebo-controlled trial of oral LNAD+ reported whole-blood intracellular NAD 53% higher versus placebo at day six; 60 adults were randomized and 50 entered the primary analysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9cf73903-df6e-575d-aec2-9a3c67e2054a","slug":"lnad-plus-formulation","display_name":"LathMized NAD+ formulation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0abce882-a8cb-516b-b785-b98df59efc88","slug":"human-whole-blood-intracellular-nad","display_name":"Whole-blood intracellular NAD measurement","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy adults aged 45–75; short phase 0/1b trial, NCT07336836, retrospectively registered.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Primary abstract only. Formulation-specific, no isotope-traced intact uptake, no inference about muscle or brain NAD; exclusions and assay details require full-report appraisal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"NAD+ collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A particular oral formulation increased a blood-cell-associated NAD measure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42530810/ · DOI 10.1007/s11357-026-02399-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"5127156d-f94f-5532-bd66-f530b0c91a4a","evidence_kind":"source_excerpt","locator":"Lines 308-314","start_line":308,"end_line":314,"excerpt":"## nad-plus-oral-formulation-blood\nA particular oral formulation increased a blood-cell-associated NAD measure.\nA five-day placebo-controlled trial of oral LNAD+ reported whole-blood intracellular NAD 53% higher versus placebo at day six; 60 adults were randomized and 50 entered the primary analysis.\nModel: Healthy adults aged 45–75; short phase 0/1b trial, NCT07336836, retrospectively registered.\nLimitations: Primary abstract only. Formulation-specific, no isotope-traced intact uptake, no inference about muscle or brain NAD; exclusions and assay details require full-report appraisal.\nEvidence access: Primary abstract\nOral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42530810/ · DOI 10.1007/s11357-026-02399-1","model_system":"Healthy adults aged 45–75; short phase 0/1b trial, NCT07336836, retrospectively registered.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f59aa302-d463-5462-876f-e21e64861eac","stable_key":"import-8c946991-97f0-55ee-8df0-00e67621962f","title":"NAD+: compartmental supply, consumption and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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