Component
TRPV1-positive cutaneous sensory function
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A 24-hour 8% capsaicin patch reduced warmth detection, heat pain, histamine itch and neurogenic flare, with little effect on touch or cold and near-complete sensory recovery by day 21.
Experimental context and source evidence
- dose
- 8% capsaicin patch for 1 or 24 hours
- duration
- 1, 7 and 21 days after removal
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Fourteen healthy human volunteers
- limitations
- This experimental 24-hour exposure exceeds ordinary patch use and does not establish efficacy in patients with neuropathic pain.
- nutrient_topic
- Capsaicin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Capsaicin
- organism
- Fourteen healthy human volunteers
- plain_language
- A 24-hour 8% capsaicin patch reduced warmth detection, heat pain, histamine itch and neurogenic flare, with little effect on touch or cold and near-complete sensory recovery by day 21.
- primary_references
- The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging. (2018). https://pubmed.ncbi.nlm.nih.gov/29845449/ DOI: 10.1007/s00221-018-5299-y
- route
- Topical
- tissue
- Quantitative sensory testing and vasomotor imaging
Capsaicin: mechanism of action and interactions (2026-09-20) · lines 88–97
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Fourteen healthy human volunteers · source_derived_draft · unverified_draft
## capsaicin-skin-selectivity A 24-hour 8% capsaicin patch reduced warmth detection, heat pain, histamine itch and neurogenic flare, with little effect on touch or cold and near-complete sensory recovery by day 21. Model/species: Fourteen healthy human volunteers Tissue/system: Quantitative sensory testing and vasomotor imaging Exposure: 8% capsaicin patch for 1 or 24 hours Route: Topical Duration: 1, 7 and 21 days after removal Limits: This experimental 24-hour exposure exceeds ordinary patch use and does not establish efficacy in patients with neuropathic pain. Primary reference: The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging. (2018). https://pubmed.ncbi.nlm.nih.gov/29845449/ DOI: 10.1007/s00221-018-5299-y Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.