{"id":"a0ccae50-b7f2-5585-9696-baf07e5237df","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-skin-selectivity","predicate":"selectively_reduces","statement":"A 24-hour 8% capsaicin patch reduced warmth detection, heat pain, histamine itch and neurogenic flare, with little effect on touch or cold and near-complete sensory recovery by day 21.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"87dffbfa-7d10-5ea0-8d06-97eabffc2e90","mechanism_event_label":"A 24-hour 8% capsaicin patch reduced warmth detection, heat pain, histamine itch and neurogenic flare, with little effect on touch or cold and near-complete sensory recovery by day 21.","subject":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"object":{"id":"c2110264-ad10-53b0-9540-855ed52ba51e","slug":"human-trpv1-positive-cutaneous-sensory-function","display_name":"TRPV1-positive cutaneous sensory function","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"87dffbfa-7d10-5ea0-8d06-97eabffc2e90","stable_key":"49fecf36-4958-5f15-8c78-9a68cba50763:capsaicin-skin-selectivity-event","event_type":"observed_relationship","label":"A 24-hour 8% capsaicin patch reduced warmth detection, heat pain, histamine itch and neurogenic flare, with little effect on touch or cold and near-complete sensory recovery by day 21.","description":"A 24-hour 8% capsaicin patch reduced warmth detection, heat pain, histamine itch and neurogenic flare, with little effect on touch or cold and near-complete sensory recovery by day 21.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9cdd3a64-5185-5998-82a6-d25c8409b998","slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c2110264-ad10-53b0-9540-855ed52ba51e","slug":"human-trpv1-positive-cutaneous-sensory-function","display_name":"TRPV1-positive cutaneous sensory function","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"8% capsaicin patch for 1 or 24 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"1, 7 and 21 days after removal","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fourteen healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This experimental 24-hour exposure exceeds ordinary patch use and does not establish efficacy in patients with neuropathic pain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Capsaicin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"capsaicin","display_name":"Capsaicin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Fourteen healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A 24-hour 8% capsaicin patch reduced warmth detection, heat pain, histamine itch and neurogenic flare, with little effect on touch or cold and near-complete sensory recovery by day 21.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging. (2018). https://pubmed.ncbi.nlm.nih.gov/29845449/ DOI: 10.1007/s00221-018-5299-y","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Topical","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Quantitative sensory testing and vasomotor imaging","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4b552fd2-0ea7-5902-9497-28745d98871d","evidence_kind":"source_excerpt","locator":"Lines 88-97","start_line":88,"end_line":97,"excerpt":"## capsaicin-skin-selectivity\nA 24-hour 8% capsaicin patch reduced warmth detection, heat pain, histamine itch and neurogenic flare, with little effect on touch or cold and near-complete sensory recovery by day 21.\nModel/species: Fourteen healthy human volunteers\nTissue/system: Quantitative sensory testing and vasomotor imaging\nExposure: 8% capsaicin patch for 1 or 24 hours\nRoute: Topical\nDuration: 1, 7 and 21 days after removal\nLimits: This experimental 24-hour exposure exceeds ordinary patch use and does not establish efficacy in patients with neuropathic pain.\nPrimary reference: The time course of brief and prolonged topical 8% capsaicin-induced desensitization in healthy volunteers evaluated by quantitative sensory testing and vasomotor imaging. (2018). https://pubmed.ncbi.nlm.nih.gov/29845449/ DOI: 10.1007/s00221-018-5299-y\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Fourteen healthy human volunteers","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"883c8afb-af48-5561-ae3b-00d4f3c26752","stable_key":"import-49fecf36-4958-5f15-8c78-9a68cba50763","title":"Capsaicin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"ea5c8dc49ffdfcec3f5542fed8be406c4af37873b76416910f88a743b733466e","revision_id":"79e49bef-520e-5503-ad2e-7de89ad236cf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}