Component

Human SLC6A6-mediated cellular taurine uptake

Context-specific entity; species, compartment and exposure are stated on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Taurine uptake by reconstituted human placental membranes required chloride; chloride kinetics supported one chloride per taurine.

    Chloride ion → Human SLC6A6-mediated cellular taurine uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human placental membrane proteoliposomes.
    limitations
    Alternative anions supported at most 30% of control uptake; this does not define a dietary chloride threshold.
    nutrient_topic
    Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
    plain_language
    Chloride is part of the transport cycle.
    primary_references
    Solubilization and functional reconstitution of the human placental taurine transporter. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8431457/ · DOI 10.1016/0005-2736(93)90296-c

    Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 121–127

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human placental membrane proteoliposomes. · source_derived_draft · unverified_draft

    ## taurine-placental-chloride Chloride is part of the transport cycle. Taurine uptake by reconstituted human placental membranes required chloride; chloride kinetics supported one chloride per taurine. Model: Human placental membrane proteoliposomes. Limitations: Alternative anions supported at most 30% of control uptake; this does not define a dietary chloride threshold. Evidence access: Primary abstract Solubilization and functional reconstitution of the human placental taurine transporter. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8431457/ · DOI 10.1016/0005-2736(93)90296-c
    Complete structured claim and evidence

  2. Replacing sodium strongly reduced taurine uptake in reconstituted human placental membranes; uptake kinetics supported two sodium ions per taurine.

    Sodium ion → Human SLC6A6-mediated cellular taurine uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human placental brush-border proteins reconstituted in proteoliposomes.
    limitations
    This was not purified SLC6A6 alone; the coupling estimate is assay-specific, not a reason to consume more sodium.
    nutrient_topic
    Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
    plain_language
    The sodium gradient helps power taurine entry.
    primary_references
    Solubilization and functional reconstitution of the human placental taurine transporter. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8431457/ · DOI 10.1016/0005-2736(93)90296-c

    Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 113–119

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human placental brush-border proteins reconstituted in proteoliposomes. · source_derived_draft · unverified_draft

    ## taurine-placental-sodium The sodium gradient helps power taurine entry. Replacing sodium strongly reduced taurine uptake in reconstituted human placental membranes; uptake kinetics supported two sodium ions per taurine. Model: Human placental brush-border proteins reconstituted in proteoliposomes. Limitations: This was not purified SLC6A6 alone; the coupling estimate is assay-specific, not a reason to consume more sodium. Evidence access: Primary abstract Solubilization and functional reconstitution of the human placental taurine transporter. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8431457/ · DOI 10.1016/0005-2736(93)90296-c
    Complete structured claim and evidence

  3. The homozygous SLC6A6 p.Ala78Glu variant was associated with approximately 95% lower taurine uptake in patient peripheral blood mononuclear cells despite membrane localization of the variant protein.

    Human taurine transporter / SLC6A6 → Human SLC6A6-mediated cellular taurine uptake source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Two affected brothers; human genetic, cell and spectroscopy studies.
    limitations
    Variant-specific inherited disease, not a universal threshold for dietary taurine insufficiency.
    nutrient_topic
    Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
    plain_language
    A transporter can reach the membrane yet function poorly.
    primary_references
    Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31345061/ · DOI 10.1096/fj.201900914RR
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 145–151

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Two affected brothers; human genetic, cell and spectroscopy studies. · source_derived_draft · unverified_draft

    ## taurine-taut-a78e A transporter can reach the membrane yet function poorly. The homozygous SLC6A6 p.Ala78Glu variant was associated with approximately 95% lower taurine uptake in patient peripheral blood mononuclear cells despite membrane localization of the variant protein. Model: Two affected brothers; human genetic, cell and spectroscopy studies. Limitations: Variant-specific inherited disease, not a universal threshold for dietary taurine insufficiency. Evidence access: Primary abstract Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31345061/ · DOI 10.1096/fj.201900914RR
    Complete structured claim and evidence

  4. SLC6A6 p.Thr249Ile and p.Ala294Thr missense variants showed complete loss of taurine transport in HEK293 cells and patient fibroblasts in the four-family study of seven affected individuals.

    Human taurine transporter / SLC6A6 → Human SLC6A6-mediated cellular taurine uptake source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Human multicenter genetic study; cellular transport experiments; final issue year 2026, online 2025.
    limitations
    Investigational supplementation was proposed, not proven effective by this study.
    nutrient_topic
    Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Taurine
    plain_language
    Some disease variants had no measurable transport in the tested cells.
    primary_references
    Early-Onset Retinopathy in Patients With Variants in SLC6A6 Leading to Impaired Taurine Transport. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41343195/ · DOI 10.1001/jamaophthalmol.2025.4875
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19) · lines 177–183

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human multicenter genetic study; cellular transport experiments; final issue year 2026, online 2025. · source_derived_draft · unverified_draft

    ## taurine-taut-new-variants Some disease variants had no measurable transport in the tested cells. SLC6A6 p.Thr249Ile and p.Ala294Thr missense variants showed complete loss of taurine transport in HEK293 cells and patient fibroblasts in the four-family study of seven affected individuals. Model: Human multicenter genetic study; cellular transport experiments; final issue year 2026, online 2025. Limitations: Investigational supplementation was proposed, not proven effective by this study. Evidence access: Primary abstract Early-Onset Retinopathy in Patients With Variants in SLC6A6 Leading to Impaired Taurine Transport. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41343195/ · DOI 10.1001/jamaophthalmol.2025.4875
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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