{"id":"49150a10-b415-5f3f-958f-accab1ddf5a6","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-placental-chloride","predicate":"couples_to","statement":"Taurine uptake by reconstituted human placental membranes required chloride; chloride kinetics supported one chloride per taurine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6464d2fd-8230-5430-b2a8-2a619aa250ab","mechanism_event_label":"Chloride is part of the transport cycle.","subject":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"object":{"id":"7258e667-abea-555f-9ee6-a4ccee0fd02a","slug":"human-taut-uptake","display_name":"Human SLC6A6-mediated cellular taurine uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6464d2fd-8230-5430-b2a8-2a619aa250ab","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-placental-chloride-event","event_type":"observed_relationship","label":"Chloride is part of the transport cycle.","description":"Taurine uptake by reconstituted human placental membranes required chloride; chloride kinetics supported one chloride per taurine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7258e667-abea-555f-9ee6-a4ccee0fd02a","slug":"human-taut-uptake","display_name":"Human SLC6A6-mediated cellular taurine uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human placental membrane proteoliposomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Alternative anions supported at most 30% of control uptake; this does not define a dietary chloride threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Chloride is part of the transport cycle.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Solubilization and functional reconstitution of the human placental taurine transporter. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8431457/ · DOI 10.1016/0005-2736(93)90296-c","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"624cd989-a9d6-5cdb-a95f-23d629ebc064","evidence_kind":"source_excerpt","locator":"Lines 121-127","start_line":121,"end_line":127,"excerpt":"## taurine-placental-chloride\nChloride is part of the transport cycle.\nTaurine uptake by reconstituted human placental membranes required chloride; chloride kinetics supported one chloride per taurine.\nModel: Human placental membrane proteoliposomes.\nLimitations: Alternative anions supported at most 30% of control uptake; this does not define a dietary chloride threshold.\nEvidence access: Primary abstract\nSolubilization and functional reconstitution of the human placental taurine transporter. · 1993 · https://pubmed.ncbi.nlm.nih.gov/8431457/ · DOI 10.1016/0005-2736(93)90296-c","model_system":"Human placental membrane proteoliposomes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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