Component
Parent-rated behavior after blinded tartrazine challenge in selected children
Experimental model, exposure and limitations remain on each linked record.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The blinded challenge identified dose-related irritability, restlessness or sleep disturbance in a subset of the selected children.
Experimental context and source evidence
- dose
- Placebo or tartrazine 1, 2, 5, 10, 20 or 50 mg each challenge morning
- duration
- 21-day repeated-measures study; ratings for each 24 h
- evidence_access
- Primary PubMed abstract; unrecovered method details explicitly retained.
- evidence_scope
- literature_reviewed; source-specific experimental curation
- experimental_model
- Selected children aged 2-14 years: 34 suspected/uncertain reactors and 20 controls
- limitations
- Recruitment enriched for suspected reactions; parent ratings and individual-response classification do not prove universal effects or a mechanism mediated by zinc.
- nutrient_topic
- Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits. · Tartrazine
- organism
- Selected children aged 2-14 years: 34 suspected/uncertain reactors and 20 controls
- plain_language
- The blinded challenge identified dose-related irritability, restlessness or sleep disturbance in a subset of the selected children.
- primary_references
- Synthetic food coloring and behavior: a dose response effect in a double-blind, placebo-controlled, repeated-measures study. (1994). https://pubmed.ncbi.nlm.nih.gov/7965420/ DOI: 10.1016/s0022-3476(94)70059-1
- route
- Oral administration
- tissue
- Blinded parent-rated behavior
Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 314–323
Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Selected children aged 2-14 years: 34 suspected/uncertain reactors and 20 controls · source_derived_draft · unverified_draft
## tartrazine-behavior-challenge The blinded challenge identified dose-related irritability, restlessness or sleep disturbance in a subset of the selected children. Model/species: Selected children aged 2-14 years: 34 suspected/uncertain reactors and 20 controls Tissue: Blinded parent-rated behavior Exposure: Placebo or tartrazine 1, 2, 5, 10, 20 or 50 mg each challenge morning Route: Oral administration Duration: 21-day repeated-measures study; ratings for each 24 h Limits: Recruitment enriched for suspected reactions; parent ratings and individual-response classification do not prove universal effects or a mechanism mediated by zinc. Primary reference: Synthetic food coloring and behavior: a dose response effect in a double-blind, placebo-controlled, repeated-measures study. (1994). https://pubmed.ncbi.nlm.nih.gov/7965420/ DOI: 10.1016/s0022-3476(94)70059-1 Access: Primary PubMed abstract; unrecovered method details explicitly retained.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.