Component
Human vascular specimens from patients with type 2 diabetes
Human vascular specimens from patients with type 2 diabetes
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Vascular specimens from patients with type 2 diabetes showed lower ATP7A protein.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- curation_topic
- copper · Copper
- experimental_condition
- Control vascular specimens Type 2 diabetes vascular specimens · Human vascular specimens from patients with type 2 diabetes Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "Type 2 diabetes vascular specimens", "comparator": "Control vascular specimens", "endpoint": "ATP7A protein abundance", "effect_direction": "decrease", "combination": "single", "conditions": [{"entity_slug": "human-t2d-vessel-state", "state": "Type 2 diabetes vascular specimens"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Human vascular specimens; primary abstract reviewed
- limitations
- Observational human finding; detailed sampling and covariate analysis require full-methods review.
- primary_references
- Sudhahar et al. 2018; DOI:10.1161/ATVBAHA.117.309819; PMID:29301787; https://pubmed.ncbi.nlm.nih.gov/29301787/
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Diabetes cascade: targeted primary-source supplement · lines 39–39
See claim-local references; curated paraphrases reviewed 2026-09-20. · supports · Human vascular specimens; primary abstract reviewed · source_derived_draft · unverified_draft
Vascular specimens from patients with type 2 diabetes showed lower ATP7A protein. Model: Human vascular specimens; primary abstract reviewed. Limits: Observational human finding; detailed sampling and covariate analysis require full-methods review. Primary reference: Sudhahar et al. 2018; DOI:10.1161/ATVBAHA.117.309819; PMID:29301787; https://pubmed.ncbi.nlm.nih.gov/29301787/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.