{"id":"799cd95b-487a-5cf7-a014-733af4fe1c7f","stable_key":"3ad23a58-d6a8-5554-81d6-9c83abd33087:t2d-human-vessel-atp7a","predicate":"reported_comparison","statement":"Vascular specimens from patients with type 2 diabetes showed lower ATP7A protein.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b298cce0-ccad-5c49-a58c-bb9ebfc7a482","mechanism_event_label":"Vascular specimens from patients with type 2 diabetes showed lower ATP7A protein.","subject":{"id":"13765cb6-f061-5c91-a825-94e7a3c07113","slug":"human-t2d-vessel-state","display_name":"Human vascular specimens from patients with type 2 diabetes","entity_type_key":"tissue"},"object":{"id":"b9f71896-3b5a-5cea-adb0-c775342c2fa4","slug":"atp7a","display_name":"Human copper-transporting ATPase ATP7A","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"b298cce0-ccad-5c49-a58c-bb9ebfc7a482","stable_key":"3ad23a58-d6a8-5554-81d6-9c83abd33087:t2d-human-vessel-atp7a","event_type":"reported_comparison","label":"Vascular specimens from patients with type 2 diabetes showed lower ATP7A protein.","description":"","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13765cb6-f061-5c91-a825-94e7a3c07113","slug":"human-t2d-vessel-state","display_name":"Human vascular specimens from patients with type 2 diabetes","entity_type_key":"tissue"},"role":"experimental_actor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b9f71896-3b5a-5cea-adb0-c775342c2fa4","slug":"atp7a","display_name":"Human copper-transporting ATPase ATP7A","entity_type_key":"protein"},"role":"measured_endpoint","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"curation_topic","value_text":"copper","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"experimental_condition","value_text":"Type 2 diabetes vascular specimens","comparator":"Control vascular specimens","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"human-t2d-vessel-state","display_name":"Human vascular specimens from patients with type 2 diabetes","entity_type_key":"tissue"}},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Type 2 diabetes vascular specimens\", \"comparator\": \"Control vascular specimens\", \"endpoint\": \"ATP7A protein abundance\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": [{\"entity_slug\": \"human-t2d-vessel-state\", \"state\": \"Type 2 diabetes vascular specimens\"}]}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Human vascular specimens; primary abstract reviewed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational human finding; detailed sampling and covariate analysis require full-methods review.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Sudhahar et al. 2018; DOI:10.1161/ATVBAHA.117.309819; PMID:29301787; https://pubmed.ncbi.nlm.nih.gov/29301787/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1733f8a8-d90e-53bc-8649-254f8e79866d","evidence_kind":"source_excerpt","locator":"Lines 39-39","start_line":39,"end_line":39,"excerpt":"Vascular specimens from patients with type 2 diabetes showed lower ATP7A protein. Model: Human vascular specimens; primary abstract reviewed. Limits: Observational human finding; detailed sampling and covariate analysis require full-methods review. Primary reference: Sudhahar et al. 2018; DOI:10.1161/ATVBAHA.117.309819; PMID:29301787; https://pubmed.ncbi.nlm.nih.gov/29301787/","model_system":"Human vascular specimens; primary abstract reviewed","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curator paraphrase of the cited primary result; see stated access scope.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8600b90c-477e-569e-9666-09321af7bc9e","stable_key":"import-3ad23a58-d6a8-5554-81d6-9c83abd33087","title":"Diabetes cascade: targeted primary-source supplement","document_type":"imported_text","citation_label":"See claim-local references; curated paraphrases reviewed 2026-09-20.","file_path":"","sha256":"0a841d67ea40a5efea21157e1a5703488b8ef63e587eea50dacac19c67894cd4","revision_id":"0faa1a78-e820-559e-a23b-5e3939f9079e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}