Component

Human first-pass splanchnic glutamate handling

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. In postabsorptive healthy adults, tracer comparisons estimated 96 ± 1% first-pass splanchnic extraction of enterally delivered glutamate.

    Human first-pass splanchnic glutamate handling → L-Glutamate source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human crossover intravenous/nasogastric tracer infusion, 3.5 hours per route in each seven-hour study.
    limitations
    Splanchnic means gut plus liver region; the percentage is protocol-specific, not a fixed value for every meal or dose.
    nutrient_topic
    L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
    plain_language
    Much of an enteral tracer was handled before reaching the general circulation.
    primary_references
    Oxidation of glutamic acid by the splanchnic bed in humans. · 1995 · https://pubmed.ncbi.nlm.nih.gov/7653544/ · DOI 10.1152/ajpendo.1995.269.2.E269

    L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 18–24

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human crossover intravenous/nasogastric tracer infusion, 3.5 hours per route in each seven-hour study. · source_derived_draft · unverified_draft

    ## glutamate-first-pass Much of an enteral tracer was handled before reaching the general circulation. In postabsorptive healthy adults, tracer comparisons estimated 96 ± 1% first-pass splanchnic extraction of enterally delivered glutamate. Model: Human crossover intravenous/nasogastric tracer infusion, 3.5 hours per route in each seven-hour study. Limitations: Splanchnic means gut plus liver region; the percentage is protocol-specific, not a fixed value for every meal or dose. Evidence access: Primary abstract Oxidation of glutamic acid by the splanchnic bed in humans. · 1995 · https://pubmed.ncbi.nlm.nih.gov/7653544/ · DOI 10.1152/ajpendo.1995.269.2.E269
    Complete structured claim and evidence

  2. About 78 ± 3% of enterally delivered carbon-labeled glutamate tracer was recovered as exhaled CO2 in the study.

    Human first-pass splanchnic glutamate handling → L-Glutamate source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human [1,2-13C2]glutamate tracer and breath CO2 measurements.
    limitations
    Whole-body breath recovery does not identify the cell type oxidizing each molecule.
    nutrient_topic
    L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · L-Glutamate
    plain_language
    Glutamate carbon was used as fuel, not merely redistributed as amino nitrogen.
    primary_references
    Oxidation of glutamic acid by the splanchnic bed in humans. · 1995 · https://pubmed.ncbi.nlm.nih.gov/7653544/ · DOI 10.1152/ajpendo.1995.269.2.E269

    L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19) · lines 26–32

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human [1,2-13C2]glutamate tracer and breath CO2 measurements. · source_derived_draft · unverified_draft

    ## glutamate-first-pass-oxidation Glutamate carbon was used as fuel, not merely redistributed as amino nitrogen. About 78 ± 3% of enterally delivered carbon-labeled glutamate tracer was recovered as exhaled CO2 in the study. Model: Human [1,2-13C2]glutamate tracer and breath CO2 measurements. Limitations: Whole-body breath recovery does not identify the cell type oxidizing each molecule. Evidence access: Primary abstract Oxidation of glutamic acid by the splanchnic bed in humans. · 1995 · https://pubmed.ncbi.nlm.nih.gov/7653544/ · DOI 10.1152/ajpendo.1995.269.2.E269
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards