{"id":"0593521a-96ab-5378-9ea2-111a4387faa7","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-first-pass","predicate":"extracts_enteral","statement":"In postabsorptive healthy adults, tracer comparisons estimated 96 ± 1% first-pass splanchnic extraction of enterally delivered glutamate.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"000c5be9-5110-515d-a62c-6e358a7bc0bb","mechanism_event_label":"Much of an enteral tracer was handled before reaching the general circulation.","subject":{"id":"9e9d067b-2fad-53a6-aace-44c2a4d6f091","slug":"human-splanchnic-glutamate-first-pass","display_name":"Human first-pass splanchnic glutamate handling","entity_type_key":"cellular_process"},"object":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"000c5be9-5110-515d-a62c-6e358a7bc0bb","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-first-pass-event","event_type":"observed_relationship","label":"Much of an enteral tracer was handled before reaching the general circulation.","description":"In postabsorptive healthy adults, tracer comparisons estimated 96 ± 1% first-pass splanchnic extraction of enterally delivered glutamate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9e9d067b-2fad-53a6-aace-44c2a4d6f091","slug":"human-splanchnic-glutamate-first-pass","display_name":"Human first-pass splanchnic glutamate handling","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human crossover intravenous/nasogastric tracer infusion, 3.5 hours per route in each seven-hour study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Splanchnic means gut plus liver region; the percentage is protocol-specific, not a fixed value for every meal or dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Much of an enteral tracer was handled before reaching the general circulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Oxidation of glutamic acid by the splanchnic bed in humans. · 1995 · https://pubmed.ncbi.nlm.nih.gov/7653544/ · DOI 10.1152/ajpendo.1995.269.2.E269","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4025a9fa-7c3d-5fd1-b0f8-d7d0f97452fb","evidence_kind":"source_excerpt","locator":"Lines 18-24","start_line":18,"end_line":24,"excerpt":"## glutamate-first-pass\nMuch of an enteral tracer was handled before reaching the general circulation.\nIn postabsorptive healthy adults, tracer comparisons estimated 96 ± 1% first-pass splanchnic extraction of enterally delivered glutamate.\nModel: Human crossover intravenous/nasogastric tracer infusion, 3.5 hours per route in each seven-hour study.\nLimitations: Splanchnic means gut plus liver region; the percentage is protocol-specific, not a fixed value for every meal or dose.\nEvidence access: Primary abstract\nOxidation of glutamic acid by the splanchnic bed in humans. · 1995 · https://pubmed.ncbi.nlm.nih.gov/7653544/ · DOI 10.1152/ajpendo.1995.269.2.E269","model_system":"Human crossover intravenous/nasogastric tracer infusion, 3.5 hours per route in each seven-hour study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c6a55239-e808-5ed7-9fa3-755a18ecb29f","stable_key":"import-b7014def-74ec-599e-8347-167e24fec1f0","title":"L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"3da83bd75fddeb96d17af72d7e2ae04344779957650f266521f6c8ebd59fb54f","revision_id":"55196c72-94e4-540a-a869-81d35647b04a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}