Component

Human SLC5A8-mediated butyrate uptake

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Probenecid or ibuprofen at 1 mM strongly inhibited human SLC5A8 activity in the oocyte assay.

    Human sodium-coupled monocarboxylate transporter 1 / SLC5A8 → Human SLC5A8-mediated butyrate uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human transporter voltage-clamp experiments.
    limitations
    High bath concentrations do not prove clinically meaningful butyrate depletion or justify changing a medicine.
    nutrient_topic
    Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
    plain_language
    Drugs can block this transporter under experimental conditions.
    primary_references
    The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15090606/ · DOI 10.1113/jphysiol.2004.063859

    Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 118–124

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human transporter voltage-clamp experiments. · source_derived_draft · unverified_draft

    ## butyrate-smct1-drug-block Drugs can block this transporter under experimental conditions. Probenecid or ibuprofen at 1 mM strongly inhibited human SLC5A8 activity in the oocyte assay. Model: Human transporter voltage-clamp experiments. Limitations: High bath concentrations do not prove clinically meaningful butyrate depletion or justify changing a medicine. Evidence access: Primary abstract The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15090606/ · DOI 10.1113/jphysiol.2004.063859
    Complete structured claim and evidence

  2. Human SMCT/SLC5A8 transport-associated currents depended on external sodium; chloride influenced part of the current but was not cotransported.

    Sodium ion → Human SLC5A8-mediated butyrate uptake source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Human transporter expressed in Xenopus oocytes.
    limitations
    Assay currents do not by themselves define a clinical electrolyte threshold or a universal coupling ratio for every substrate.
    nutrient_topic
    Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
    plain_language
    Sodium dependence is different from chloride being a transported substrate.
    primary_references
    The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15090606/ · DOI 10.1113/jphysiol.2004.063859
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 110–116

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human transporter expressed in Xenopus oocytes. · source_derived_draft · unverified_draft

    ## butyrate-smct1-sodium-loss Sodium dependence is different from chloride being a transported substrate. Human SMCT/SLC5A8 transport-associated currents depended on external sodium; chloride influenced part of the current but was not cotransported. Model: Human transporter expressed in Xenopus oocytes. Limitations: Assay currents do not by themselves define a clinical electrolyte threshold or a universal coupling ratio for every substrate. Evidence access: Primary abstract The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15090606/ · DOI 10.1113/jphysiol.2004.063859
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Expressing human intestinal SLC5A8 in Xenopus oocytes increased butyrate uptake and generated sodium-dependent inward currents.

    Human sodium-coupled monocarboxylate transporter 1 / SLC5A8 → Butyrate source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human SLC5A8 expressed in frog oocytes; radiotracer and voltage-clamp assays.
    limitations
    Expression host is not the protein species. This does not establish that extra dietary sodium improves uptake.
    nutrient_topic
    Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Butyrate
    plain_language
    A human transporter can concentrate butyrate using a sodium gradient.
    primary_references
    Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids. · 2004 · https://pubmed.ncbi.nlm.nih.gov/14966140/ · DOI 10.1074/jbc.C400059200
    transport_effect
    raises Expression increased butyrate uptake and generated sodium-dependent inward currents.
    transport_pool
    the expressing cell Expression increased butyrate uptake and generated sodium-dependent inward currents.

    Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19) · lines 102–108

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human SLC5A8 expressed in frog oocytes; radiotracer and voltage-clamp assays. · source_derived_draft · unverified_draft

    ## butyrate-smct1-uptake A human transporter can concentrate butyrate using a sodium gradient. Expressing human intestinal SLC5A8 in Xenopus oocytes increased butyrate uptake and generated sodium-dependent inward currents. Model: Human SLC5A8 expressed in frog oocytes; radiotracer and voltage-clamp assays. Limitations: Expression host is not the protein species. This does not establish that extra dietary sodium improves uptake. Evidence access: Primary abstract Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids. · 2004 · https://pubmed.ncbi.nlm.nih.gov/14966140/ · DOI 10.1074/jbc.C400059200
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards