Component
Experimentally tested human SECIS elements
The collection of human selenocysteine insertion sequence elements compared in the reporter experiment; distinct from either SELENOP-specific element.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human SECIS elements show widely differing reporter recoding activities, precluding a universal endogenous 5–10 percent efficiency inference.
Experimental context and source evidence
- cell_type
- HEK293 and HepG2 reporters
- experimental_model
- 26 human SECIS reporters in HEK293/HepG2 and cell-free translation
- limitations
- Reporter activity is not a direct count of all endogenous translation outcomes.
- organism
- Homo sapiens
Selenium: literature corrections and mechanism additions · lines 1203–1213
Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually · supports · 26 human SECIS reporters in HEK293/HepG2 and cell-free translation · secondary_verified · secondary_verified
## secis-variable Efficiency depends on the RNA and test conditions. Human SECIS elements show widely differing reporter recoding activities, precluding a universal endogenous 5–10 percent efficiency inference. Organism: Homo sapiens Cell type: HEK293 and HepG2 reporters Experimental model: 26 human SECIS reporters in HEK293/HepG2 and cell-free translation Limitations: Reporter activity is not a direct count of all endogenous translation outcomes. Primary reference: [Novel structural determinants in human SECIS elements modulate the translational recoding of UGA as selenocysteine](https://pmc.ncbi.nlm.nih.gov/articles/PMC2761289/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.