Component
Human sebocyte type-I 5-alpha-reductase ELISA amount
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The 0.03 wt% mixture lowered the type-I 5α-reductase ELISA signal more than SA alone under testosterone challenge.
Experimental context and source evidence
- evidence_access
- Primary full-text methods/results reviewed. Published January 2026 despite 2025 in DOI.
- experimental_contrast
- {"intervention": "1:1 SA/P. mume mixture plus testosterone", "comparator": "SA alone plus testosterone", "endpoint": "The 0.03 wt% mixture lowered the type-I 5α-reductase ELISA signal more than SA alone under testosterone challenge.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Human sebocytes; 10 nM testosterone, 72 h; three technical replicates.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- ELISA protein amount in processed supernatant, not catalytic inhibition. No total-protein normalization or independent biological replication established.
- plain_language
- The 0.03 wt% mixture lowered the type-I 5α-reductase ELISA signal more than SA alone under testosterone challenge.
- primary_references
- Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment | 2026 | DOI 10.3389/fntpr.2025.1737986 | https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full
- source_locator
- Reviewed reference lines 79-79; exact primary location described in quoted passage where extracted.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 79–79
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human sebocytes; 10 nM testosterone, 72 h; three technical replicates. · source_derived_draft · unverified_draft
**A 2026 topical study measured protein amount.** Human sebocytes challenged with 10 nM testosterone were exposed for 72 h to shikimic acid or a 1:1 shikimic-acid/Prunus mume extract mixture. At 0.03 wt%, the mixture lowered the reported type-I 5α-reductase ELISA signal more than shikimic acid alone. The assay measured protein amount in processed supernatant, with three technical replicates and no total-protein normalization; it was not a testosterone-to-DHT catalytic assay. Docking is not measured affinity. Thus a direct 5α-reductase inhibition claim is not justified by this experiment. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.