Component
Erythrocyte GSH/GSSG balance during garlic-juice exposure
Erythrocyte GSH/GSSG balance during garlic-juice exposure. Interpret through the linked study species, preparation, exposure and measured endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Without glucose, garlic exposure decreased the reduced-to-oxidized GSH balance while conserving total glutathione equivalents.
Experimental context and source evidence
- evidence_access
- Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
- experimental_condition
- Garlic exposure with glucose present · Garlic juice tested in the 2007 erythrocyte and vessel study Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- Garlic exposure with glucose absent · D-glucose Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "Garlic exposure without glucose", "comparator": "Garlic exposure with glucose", "endpoint": "Without glucose, garlic exposure decreased the reduced-to-oxidized GSH balance while conserving total glutathione equivalents.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "garlic-juice-benavides-2007", "state": "present"}, {"entity_slug": "glucose", "state": "absent"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Human RBC biochemical measurements; matched glucose conditions.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Redox balance change, not disappearance of all sulfur or proven nutrient deficiency in a patient.
- plain_language
- Without glucose, garlic exposure decreased the reduced-to-oxidized GSH balance while conserving total glutathione equivalents.
- primary_references
- Hydrogen sulfide mediates the vasoactivity of garlic. | 2007 | DOI 10.1073/pnas.0705710104 | PMID 17951430 | https://pubmed.ncbi.nlm.nih.gov/17951430/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC2084282/ | https://doi.org/10.1073/pnas.0705710104
- source_locator
- Reviewed reference lines 79-79; exact primary location described in quoted passage where extracted.
Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 79–79
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human RBC biochemical measurements; matched glucose conditions. · Recorded from source · Recorded from source
**Glucose and erythrocyte redox state.** In isolated human erythrocytes, glucose sustained sulfide production during repeated garlic-juice exposures. Without glucose, production capacity declined and the GSH/GSSG balance shifted despite conserved total glutathione equivalents. This is a resource-dependent ex vivo observation. NADPH production through the pentose-phosphate pathway was a proposed explanation, not a selective G6PD perturbation or proof of a B2-dependent clinical response. [Benavides 2007](https://pmc.ncbi.nlm.nih.gov/articles/PMC2084282/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.