Component
Human prostate-cancer glucose uptake during cucurbitacin D exposure
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Cucurbitacin D at 0.1–1 micromolar reduced glucose uptake and lactate output in human PC3 and DU145 experiments.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human prostate-cancer cell experiments; xenografts also studied.
- limitations
- Not evidence of effective or safe diabetes treatment.
- nutrient_topic
- Cucurbitacins collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Cucurbitacins
- plain_language
- Fuel handling changed in these cancer cells.
- primary_references
- Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30875788/ · DOI 10.3390/cancers11030364
Cucurbitacins: thiol chemistry, cytoskeleton, metabolic dependencies and signaling (2026-09-20) · lines 308–314
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human prostate-cancer cell experiments; xenografts also studied. · source_derived_draft · unverified_draft
## cucurbitacin-d-glucose Fuel handling changed in these cancer cells. Cucurbitacin D at 0.1–1 micromolar reduced glucose uptake and lactate output in human PC3 and DU145 experiments. Model: Human prostate-cancer cell experiments; xenografts also studied. Limitations: Not evidence of effective or safe diabetes treatment. Evidence access: Primary abstract Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30875788/ · DOI 10.3390/cancers11030364
Complete structured claim and evidence
Where it participates (unsigned role)
Cucurbitacin D decreased GLUT1 expression in the prostate-cancer study; miR-132-associated changes were also reported.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human PC3/DU145 cells and xenograft work.
- limitations
- Expression and correlated microRNA changes do not establish a single exclusive mechanism.
- nutrient_topic
- Cucurbitacins collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Cucurbitacins
- plain_language
- Transporter abundance offers one route to altered glucose handling.
- primary_references
- Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30875788/ · DOI 10.3390/cancers11030364
Cucurbitacins: thiol chemistry, cytoskeleton, metabolic dependencies and signaling (2026-09-20) · lines 316–322
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human PC3/DU145 cells and xenograft work. · source_derived_draft · unverified_draft
## cucurbitacin-d-glut1-expression Transporter abundance offers one route to altered glucose handling. Cucurbitacin D decreased GLUT1 expression in the prostate-cancer study; miR-132-associated changes were also reported. Model: Human PC3/DU145 cells and xenograft work. Limitations: Expression and correlated microRNA changes do not establish a single exclusive mechanism. Evidence access: Primary abstract Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30875788/ · DOI 10.3390/cancers11030364
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.