Component

Human postprandial triglyceride response

Human postprandial triglyceride response. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The 3-g Ceylon cinnamon high-fat-meal experiment found no effect on postprandial triglycerides.

    C. zeylanicum spice, 3 g with a high-fat meal in 2011 → Human postprandial triglyceride response source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/ceylon-research/21899741.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d49880de3ff914aa03404f38b7590f5905e069135a693cd0bc2aca626c0a9493", "start_char": 0, "end_char": 1845, "text_sha256": "d49880de3ff914aa03404f38b7590f5905e069135a693cd0bc2aca626c0a9493"}
    experimental_model
    Single-blind randomized crossover meal experiment
    exposure
    3 g C. zeylanicum with a high-fat meal; 360-minute observation
    limitations
    Small acute meal experiment; a null result here is not inconsistent with every longer extract trial. Abstract has an inconsistent parenthetical p-value, so no numeric p-value is asserted here.
    nutrient_topic
    Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
    organism
    Human
    plain_language
    Adding this amount of spice to the test meal did not produce the expected change in postprandial triglycerides.
    primary_references
    [ceylon-p21899741] Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. (2011). https://pubmed.ncbi.nlm.nih.gov/21899741/ DOI: 10.1186/1475-2840-10-78
    tissue_or_cell_type
    Nine healthy young adults

    Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 1247–1258

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Single-blind randomized crossover meal experiment · source_derived_draft · unverified_draft

    ### ceylon-meal-tg The 3-g Ceylon cinnamon high-fat-meal experiment found no effect on postprandial triglycerides. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: Adding this amount of spice to the test meal did not produce the expected change in postprandial triglycerides. organism: Human tissue_or_cell_type: Nine healthy young adults experimental_model: Single-blind randomized crossover meal experiment limitations: Small acute meal experiment; a null result here is not inconsistent with every longer extract trial. Abstract has an inconsistent parenthetical p-value, so no numeric p-value is asserted here. exposure: 3 g C. zeylanicum with a high-fat meal; 360-minute observation evidence_span: {"source_cache": "artifacts/ceylon-research/21899741.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d49880de3ff914aa03404f38b7590f5905e069135a693cd0bc2aca626c0a9493", "start_char": 0, "end_char": 1845, "text_sha256": "d49880de3ff914aa03404f38b7590f5905e069135a693cd0bc2aca626c0a9493"} [ceylon-p21899741] Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. (2011). https://pubmed.ncbi.nlm.nih.gov/21899741/ DOI: 10.1186/1475-2840-10-78
    Complete structured claim and evidence

  2. In the eight-man subset, HFCS and sucrose produced postprandial triglyceride responses comparable to pure fructose.

    HFCS-55 → Human postprandial triglyceride response source_derived_draftungraded
    Experimental context and source evidence
    dose
    HFCS or sucrose beverages with 3 isocaloric meals; exact sugar allocation not recovered from primary abstract
    duration
    24-hour profiles
    evidence_access
    Primary abstract/metadata; unrecovered methods explicitly retained.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    34 adults in crossover meal study; 8 men also received pure monosaccharides
    exposure_scope
    Direct HFCS versus sucrose
    limitations
    Short feeding study; eight-man fructose/glucose comparison is a subset and does not establish long-term equivalence or appetite control.
    nutrient_topic
    HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished. · High-Fructose Corn Syrup / HFCS
    organism
    34 adults in crossover meal study; 8 men also received pure monosaccharides
    plain_language
    In the eight-man subset, HFCS and sucrose produced postprandial triglyceride responses comparable to pure fructose.
    primary_references
    Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. (2008). https://pubmed.ncbi.nlm.nih.gov/18469239/ DOI: 10.1093/ajcn/87.5.1194
    route
    Oral beverages with meals
    tissue
    24-hour endocrine and triglyceride profiles

    High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20) · lines 377–387

    Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · 34 adults in crossover meal study; 8 men also received pure monosaccharides · source_derived_draft · unverified_draft

    ## hfcs-acute-tg In the eight-man subset, HFCS and sucrose produced postprandial triglyceride responses comparable to pure fructose. Model/species: 34 adults in crossover meal study; 8 men also received pure monosaccharides Tissue: 24-hour endocrine and triglyceride profiles Exposure: HFCS or sucrose beverages with 3 isocaloric meals; exact sugar allocation not recovered from primary abstract Route: Oral beverages with meals Duration: 24-hour profiles Exposure scope: Direct HFCS versus sucrose Limits: Short feeding study; eight-man fructose/glucose comparison is a subset and does not establish long-term equivalence or appetite control. Reference: Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. (2008). https://pubmed.ncbi.nlm.nih.gov/18469239/ DOI: 10.1093/ajcn/87.5.1194 Access: Primary abstract/metadata; unrecovered methods explicitly retained.
    Complete structured claim and evidence

  3. HFCS beverage dose was associated with increasing postprandial triglycerides; all three sugar doses exceeded the aspartame control.

    HFCS-55 → Human postprandial triglyceride response source_derived_draftungraded
    Experimental context and source evidence
    dose
    HFCS-55 beverages at 0%, 10%, 17.5% or 25% energy requirement; 0% aspartame control
    duration
    Approximately 2 weeks
    evidence_access
    Primary abstract/metadata; unrecovered methods explicitly retained.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    85 adults aged 18-40; nonrandomized double-blinded matched groups
    exposure_scope
    Direct HFCS-55 evidence
    limitations
    Short biomarker study; outpatient calories were not fixed and clinical cardiovascular events were not measured. NCT01103921 overlaps HFCS/control participants with the 2021 report.
    nutrient_topic
    HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished. · High-Fructose Corn Syrup / HFCS
    organism
    85 adults aged 18-40; nonrandomized double-blinded matched groups
    plain_language
    HFCS beverage dose was associated with increasing postprandial triglycerides; all three sugar doses exceeded the aspartame control.
    primary_references
    A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. (2015). https://pubmed.ncbi.nlm.nih.gov/25904601/ DOI: 10.3945/ajcn.114.100461
    route
    Oral beverages, with outpatient ad libitum diet and controlled inpatient meals
    tissue
    Circulating lipids and urate

    High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20) · lines 281–291

    Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · 85 adults aged 18-40; nonrandomized double-blinded matched groups · source_derived_draft · unverified_draft

    ## hfcs-dose-triglycerides HFCS beverage dose was associated with increasing postprandial triglycerides; all three sugar doses exceeded the aspartame control. Model/species: 85 adults aged 18-40; nonrandomized double-blinded matched groups Tissue: Circulating lipids and urate Exposure: HFCS-55 beverages at 0%, 10%, 17.5% or 25% energy requirement; 0% aspartame control Route: Oral beverages, with outpatient ad libitum diet and controlled inpatient meals Duration: Approximately 2 weeks Exposure scope: Direct HFCS-55 evidence Limits: Short biomarker study; outpatient calories were not fixed and clinical cardiovascular events were not measured. NCT01103921 overlaps HFCS/control participants with the 2021 report. Reference: A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. (2015). https://pubmed.ncbi.nlm.nih.gov/25904601/ DOI: 10.3945/ajcn.114.100461 Access: Primary abstract/metadata; unrecovered methods explicitly retained.
    Complete structured claim and evidence

  4. Sucrose beverages increased postprandial triglycerides compared with aspartame after the intervention.

    Sucrose → Human postprandial triglyceride response source_derived_draftungraded
    Experimental context and source evidence
    dose
    Sucrose or HFCS beverages at 25% of energy requirement versus aspartame, 3 servings/day
    duration
    16 days, approximately two weeks
    evidence_access
    Primary full-text methods/results and metadata inspected.
    evidence_scope
    literature_reviewed; source-specific curation
    experimental_model
    75 adults in nonrandomized double-blind matched groups; sucrose n=24, HFCS n=28, aspartame n=23
    exposure_scope
    Direct sucrose beverage comparison
    limitations
    Nonrandomized; paired MRI n=23 sucrose, 23 HFCS, 20 control. Outpatient calories not clamped; weight adjustment does not establish calorie independence. HFCS/control participants and some plasma outcomes overlap PMID 25904601. Short biomarkers are not clinical disease incidence.
    nutrient_topic
    Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
    organism
    75 adults in nonrandomized double-blind matched groups; sucrose n=24, HFCS n=28, aspartame n=23
    plain_language
    Sucrose beverages increased postprandial triglycerides compared with aspartame after the intervention.
    primary_references
    Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults. (2021). https://pubmed.ncbi.nlm.nih.gov/34265055/ DOI: 10.1210/clinem/dgab508
    route
    Oral beverages; outpatient usual diet, controlled inpatient meal substitutions
    tissue
    MRI liver fat, OGTT-derived insulin sensitivity and plasma markers

    Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 355–365

    Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · 75 adults in nonrandomized double-blind matched groups; sucrose n=24, HFCS n=28, aspartame n=23 · source_derived_draft · unverified_draft

    ## sucrose-triglycerides Sucrose beverages increased postprandial triglycerides compared with aspartame after the intervention. Model/species: 75 adults in nonrandomized double-blind matched groups; sucrose n=24, HFCS n=28, aspartame n=23 Tissue: MRI liver fat, OGTT-derived insulin sensitivity and plasma markers Exposure: Sucrose or HFCS beverages at 25% of energy requirement versus aspartame, 3 servings/day Route: Oral beverages; outpatient usual diet, controlled inpatient meal substitutions Duration: 16 days, approximately two weeks Exposure scope: Direct sucrose beverage comparison Limits: Nonrandomized; paired MRI n=23 sucrose, 23 HFCS, 20 control. Outpatient calories not clamped; weight adjustment does not establish calorie independence. HFCS/control participants and some plasma outcomes overlap PMID 25904601. Short biomarkers are not clinical disease incidence. Reference: Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults. (2021). https://pubmed.ncbi.nlm.nih.gov/34265055/ DOI: 10.1210/clinem/dgab508 Access: Primary full-text methods/results and metadata inspected.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards