{"id":"a33bd43e-7856-589a-af3e-3ff8f781535b","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-meal-tg","predicate":"has_no_detected_effect","statement":"The 3-g Ceylon cinnamon high-fat-meal experiment found no effect on postprandial triglycerides.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ca494e81-096d-5e4c-8087-baff52868e4c","mechanism_event_label":"Adding this amount of spice to the test meal did not produce the expected change in postprandial triglycerides.","subject":{"id":"ea892965-916a-53ce-b41e-282a379aedf1","slug":"ceylon-3g-meal","display_name":"C. zeylanicum spice, 3 g with a high-fat meal in 2011","entity_type_key":"chemical_species"},"object":{"id":"353119ae-192e-5b12-b882-814e47b1f239","slug":"human-postprandial-triglycerides","display_name":"Human postprandial triglyceride response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ca494e81-096d-5e4c-8087-baff52868e4c","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-meal-tg-event","event_type":"observed_intervention","label":"Adding this amount of spice to the test meal did not produce the expected change in postprandial triglycerides.","description":"The 3-g Ceylon cinnamon high-fat-meal experiment found no effect on postprandial triglycerides.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ea892965-916a-53ce-b41e-282a379aedf1","slug":"ceylon-3g-meal","display_name":"C. zeylanicum spice, 3 g with a high-fat meal in 2011","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"353119ae-192e-5b12-b882-814e47b1f239","slug":"human-postprandial-triglycerides","display_name":"Human postprandial triglyceride response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/21899741.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d49880de3ff914aa03404f38b7590f5905e069135a693cd0bc2aca626c0a9493\", \"start_char\": 0, \"end_char\": 1845, \"text_sha256\": \"d49880de3ff914aa03404f38b7590f5905e069135a693cd0bc2aca626c0a9493\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single-blind randomized crossover meal experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"3 g C. zeylanicum with a high-fat meal; 360-minute observation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small acute meal experiment; a null result here is not inconsistent with every longer extract trial. Abstract has an inconsistent parenthetical p-value, so no numeric p-value is asserted here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding this amount of spice to the test meal did not produce the expected change in postprandial triglycerides.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p21899741] Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. (2011). https://pubmed.ncbi.nlm.nih.gov/21899741/ DOI: 10.1186/1475-2840-10-78","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Nine healthy young adults","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bbd126a2-c9a1-51ae-acc4-e9313452838a","evidence_kind":"source_excerpt","locator":"Lines 1247-1258","start_line":1247,"end_line":1258,"excerpt":"### ceylon-meal-tg\nThe 3-g Ceylon cinnamon high-fat-meal experiment found no effect on postprandial triglycerides.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Adding this amount of spice to the test meal did not produce the expected change in postprandial triglycerides.\norganism: Human\ntissue_or_cell_type: Nine healthy young adults\nexperimental_model: Single-blind randomized crossover meal experiment\nlimitations: Small acute meal experiment; a null result here is not inconsistent with every longer extract trial. Abstract has an inconsistent parenthetical p-value, so no numeric p-value is asserted here.\nexposure: 3 g C. zeylanicum with a high-fat meal; 360-minute observation\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/21899741.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d49880de3ff914aa03404f38b7590f5905e069135a693cd0bc2aca626c0a9493\", \"start_char\": 0, \"end_char\": 1845, \"text_sha256\": \"d49880de3ff914aa03404f38b7590f5905e069135a693cd0bc2aca626c0a9493\"}\n[ceylon-p21899741] Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. 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