Component
Human postprandial circulating apolipoprotein B-48
Species, exposure, manipulation and limitations are specified on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Acarbose pretreatment prevented the 120-minute ApoB-48 increase after the sucrose-containing mixed meal.
Experimental context and source evidence
- dose
- Meal with 50 g added sucrose in 200 mL; with or without 100 mg acarbose before meal
- duration
- GLP-1 through 60 minutes; ApoB-48 at 120 minutes
- evidence_access
- Primary full-text methods/results and metadata inspected.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- Healthy Japanese men; 21 total, 12 in acarbose comparison
- exposure_scope
- Sucrose-containing mixed meal, drug and peptide response
- limitations
- Mixed meal includes starch, protein and fat. Association does not prove intact sucrose sensing by human L cells or GLP-1 mediation of ApoB-48; proposed paracrine mechanism remains a hypothesis.
- nutrient_topic
- Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
- organism
- Healthy Japanese men; 21 total, 12 in acarbose comparison
- plain_language
- Acarbose pretreatment prevented the 120-minute ApoB-48 increase after the sucrose-containing mixed meal.
- primary_references
- Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar vs non-nutritive sweetener. (2012). https://pubmed.ncbi.nlm.nih.gov/24843559/ DOI: 10.1111/j.2040-1124.2011.00163.x
- route
- Oral mixed meal and drug
- tissue
- Plasma active GLP-1 and ApoB-48 after mixed meal
Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 283–293
Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · Healthy Japanese men; 21 total, 12 in acarbose comparison · source_derived_draft · unverified_draft
## sucrose-acarbose-apob48 Acarbose pretreatment prevented the 120-minute ApoB-48 increase after the sucrose-containing mixed meal. Model/species: Healthy Japanese men; 21 total, 12 in acarbose comparison Tissue: Plasma active GLP-1 and ApoB-48 after mixed meal Exposure: Meal with 50 g added sucrose in 200 mL; with or without 100 mg acarbose before meal Route: Oral mixed meal and drug Duration: GLP-1 through 60 minutes; ApoB-48 at 120 minutes Exposure scope: Sucrose-containing mixed meal, drug and peptide response Limits: Mixed meal includes starch, protein and fat. Association does not prove intact sucrose sensing by human L cells or GLP-1 mediation of ApoB-48; proposed paracrine mechanism remains a hypothesis. Reference: Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar vs non-nutritive sweetener. (2012). https://pubmed.ncbi.nlm.nih.gov/24843559/ DOI: 10.1111/j.2040-1124.2011.00163.x Access: Primary full-text methods/results and metadata inspected.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.