Component
Human paraoxonase 2 / PON2
Species, assay, exposure and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Purified human PON2 showed no detectable gamma-nonalactone hydrolysis under the reported conditions.
Experimental context and source evidence
- dose
- Gamma-nonalactone 1 mM; Table 2 specific activities from 2-4 measurements
- duration
- PON2 non-detection tested up to 10 min at 37 C; exact positive-rate sampling interval not recovered
- evidence_access
- Primary publisher Table 2, footnote and surrounding results plus PubMed abstract; complete assay methods not recovered.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Purified recombinant human PON1, PON2 and PON3, expressed in insect cells
- limitations
- Gamma-nonalactone is a substrate, not a demonstrated PON activator. Buffer details were not recovered from the accessed table excerpt; physiological clearance and calcium-deficiency effects are unmeasured.
- nutrient_topic
- Gamma-nonalactone flavor-compound chapter; nutrient and drug interactions retain their experimental settings. · Gamma-nonalactone
- organism
- Purified recombinant human PON1, PON2 and PON3, expressed in insect cells
- plain_language
- Purified human PON2 showed no detectable gamma-nonalactone hydrolysis under the reported conditions.
- primary_references
- Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. (2005). https://pubmed.ncbi.nlm.nih.gov/15772423/ DOI: 10.1194/jlr.M400511-JLR200
- route
- In vitro enzyme/substrate incubation
- tissue
- Cell-free lactone-hydrolysis assay
Gamma-nonalactone: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 125–134
Original AI-assisted curation of eight primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Purified recombinant human PON1, PON2 and PON3, expressed in insect cells · source_derived_draft · unverified_draft
## gamma-nonalactone-pon2-null Purified human PON2 showed no detectable gamma-nonalactone hydrolysis under the reported conditions. Model/species: Purified recombinant human PON1, PON2 and PON3, expressed in insect cells Tissue: Cell-free lactone-hydrolysis assay Exposure: Gamma-nonalactone 1 mM; Table 2 specific activities from 2-4 measurements Route: In vitro enzyme/substrate incubation Duration: PON2 non-detection tested up to 10 min at 37 C; exact positive-rate sampling interval not recovered Limits: Gamma-nonalactone is a substrate, not a demonstrated PON activator. Buffer details were not recovered from the accessed table excerpt; physiological clearance and calcium-deficiency effects are unmeasured. Primary reference: Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. (2005). https://pubmed.ncbi.nlm.nih.gov/15772423/ DOI: 10.1194/jlr.M400511-JLR200 Access: Primary publisher Table 2, footnote and surrounding results plus PubMed abstract; complete assay methods not recovered.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.