Component
Glutathione pool in activated human polymorphonuclear leukocytes
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Activated human polymorphonuclear leukocytes exposed to 100 micromolar eugenol lost about 90% of intracellular glutathione over 30 minutes.
Experimental context and source evidence
- dose
- Eugenol 100 micromolar
- duration
- 30 minutes
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Phorbol-ester-stimulated human polymorphonuclear leukocytes
- limitations
- The large loss required activated cells and a high direct exposure; it is not evidence that culinary cloves cause systemic glutathione deficiency.
- nutrient_topic
- Eugenol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Eugenol
- organism
- Phorbol-ester-stimulated human polymorphonuclear leukocytes
- plain_language
- Activated human polymorphonuclear leukocytes exposed to 100 micromolar eugenol lost about 90% of intracellular glutathione over 30 minutes.
- primary_references
- Metabolic activation of eugenol by myeloperoxidase and polymorphonuclear leukocytes. (1989). https://pubmed.ncbi.nlm.nih.gov/2562421/ DOI: 10.1021/tx00009a011
- route
- In vitro
- tissue
- Intracellular glutathione and oxidative burst
Eugenol: mechanism of action and interactions (2026-09-20) · lines 99–108
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Phorbol-ester-stimulated human polymorphonuclear leukocytes · source_derived_draft · unverified_draft
## eugenol-gsh-depletion Activated human polymorphonuclear leukocytes exposed to 100 micromolar eugenol lost about 90% of intracellular glutathione over 30 minutes. Model/species: Phorbol-ester-stimulated human polymorphonuclear leukocytes Tissue/system: Intracellular glutathione and oxidative burst Exposure: Eugenol 100 micromolar Route: In vitro Duration: 30 minutes Limits: The large loss required activated cells and a high direct exposure; it is not evidence that culinary cloves cause systemic glutathione deficiency. Primary reference: Metabolic activation of eugenol by myeloperoxidase and polymorphonuclear leukocytes. (1989). https://pubmed.ncbi.nlm.nih.gov/2562421/ DOI: 10.1021/tx00009a011 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.