Component
Human NFE2L2 transcript abundance
Human NFE2L2 transcript abundance. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Mangiferin did not change the Nrf2 mRNA level in this study.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/24626801.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "01992b219c903dddc6e69f5fef95f73cec06cdaac0fd2c5bc2ff7b53b52192cd", "start_char": 0, "end_char": 1659, "text_sha256": "01992b219c903dddc6e69f5fef95f73cec06cdaac0fd2c5bc2ff7b53b52192cd"}
- experimental_model
- Cycloheximide chase and immunoprecipitation
- exposure
- Mangiferin 50 micromolar for four hours in half-life experiment
- limitations
- Cancer cell line; no direct KEAP1-binding assignment or human systemic target-engagement inference.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- Homo sapiens
- plain_language
- The protein increase did not require more measured transcript.
- primary_references
- [mangiferin-p24626801] Mangiferin increases Nrf2 protein stability by inhibiting its ubiquitination and degradation in human HL60 myeloid leukemia cells. (2014). https://pubmed.ncbi.nlm.nih.gov/24626801/ DOI: 10.3892/ijmm.2014.1696
- tissue_or_cell_type
- HL-60 myeloid leukemia cells
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 549–560
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cycloheximide chase and immunoprecipitation · source_derived_draft · unverified_draft
### mangiferin-nrf2-transcript-null Mangiferin did not change the Nrf2 mRNA level in this study. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The protein increase did not require more measured transcript. organism: Homo sapiens tissue_or_cell_type: HL-60 myeloid leukemia cells experimental_model: Cycloheximide chase and immunoprecipitation limitations: Cancer cell line; no direct KEAP1-binding assignment or human systemic target-engagement inference. exposure: Mangiferin 50 micromolar for four hours in half-life experiment evidence_span: {"source_cache": "artifacts/mangiferin-research/24626801.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "01992b219c903dddc6e69f5fef95f73cec06cdaac0fd2c5bc2ff7b53b52192cd", "start_char": 0, "end_char": 1659, "text_sha256": "01992b219c903dddc6e69f5fef95f73cec06cdaac0fd2c5bc2ff7b53b52192cd"} [mangiferin-p24626801] Mangiferin increases Nrf2 protein stability by inhibiting its ubiquitination and degradation in human HL60 myeloid leukemia cells. (2014). https://pubmed.ncbi.nlm.nih.gov/24626801/ DOI: 10.3892/ijmm.2014.1696
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.