Component
Human neonatal heel-lance Premature Infant Pain Profile score
Species, exposure, manipulation and limitations are specified on each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Oral sucrose lowered the composite PIPP score after heel lance compared with water in the neonatal randomized trial.
Experimental context and source evidence
- dose
- 0.5 mL of 24% sucrose versus 0.5 mL sterile water
- duration
- 2 minutes before lance; acute responses
- evidence_access
- Primary full-text methods/results and metadata inspected.
- evidence_scope
- literature_reviewed; source-specific curation
- experimental_model
- 59 newborn infants randomized; 44 included in primary EEG analysis
- exposure_scope
- Neonatal sensory and nociceptive endpoints
- limitations
- Twenty sucrose and 24 water infants in primary EEG analysis. Different pain-related readouts are not interchangeable. Null EEG/reflex results are not universal clinical guidance; no opioid receptor mechanism was tested.
- nutrient_topic
- Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism. · Sucrose
- organism
- 59 newborn infants randomized; 44 included in primary EEG analysis
- plain_language
- Oral sucrose lowered the composite PIPP score after heel lance compared with water in the neonatal randomized trial.
- primary_references
- Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. (2010). https://pubmed.ncbi.nlm.nih.gov/20817247/ DOI: 10.1016/S0140-6736(10)61303-7
- route
- Oral solution before clinically required heel lance
- tissue
- Heel-lance behavioral score, EEG and spinal reflex
Sucrose: mechanism of action and metabolic impact (2026-09-20) · lines 475–485
Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text. · supports · 59 newborn infants randomized; 44 included in primary EEG analysis · source_derived_draft · unverified_draft
## sucrose-neonatal-pipp Oral sucrose lowered the composite PIPP score after heel lance compared with water in the neonatal randomized trial. Model/species: 59 newborn infants randomized; 44 included in primary EEG analysis Tissue: Heel-lance behavioral score, EEG and spinal reflex Exposure: 0.5 mL of 24% sucrose versus 0.5 mL sterile water Route: Oral solution before clinically required heel lance Duration: 2 minutes before lance; acute responses Exposure scope: Neonatal sensory and nociceptive endpoints Limits: Twenty sucrose and 24 water infants in primary EEG analysis. Different pain-related readouts are not interchangeable. Null EEG/reflex results are not universal clinical guidance; no opioid receptor mechanism was tested. Reference: Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. (2010). https://pubmed.ncbi.nlm.nih.gov/20817247/ DOI: 10.1016/S0140-6736(10)61303-7 Access: Primary full-text methods/results and metadata inspected.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
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Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.