{"id":"4efc7195-a718-5b36-9eea-7e1b3fb17aed","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-neonatal-pipp","predicate":"reduces","statement":"Oral sucrose lowered the composite PIPP score after heel lance compared with water in the neonatal randomized trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b66fbf70-d24e-59a1-a35d-61ffd9c25871","mechanism_event_label":"Oral sucrose lowered the composite PIPP score after heel lance compared with water in the neonatal randomized trial.","subject":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"object":{"id":"5742057a-821e-593c-a124-b95759bb7678","slug":"human-neonatal-heel-lance-pipp","display_name":"Human neonatal heel-lance Premature Infant Pain Profile score","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b66fbf70-d24e-59a1-a35d-61ffd9c25871","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-neonatal-pipp-event","event_type":"observed_relationship","label":"Oral sucrose lowered the composite PIPP score after heel lance compared with water in the neonatal randomized trial.","description":"Oral sucrose lowered the composite PIPP score after heel lance compared with water in the neonatal randomized trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5742057a-821e-593c-a124-b95759bb7678","slug":"human-neonatal-heel-lance-pipp","display_name":"Human neonatal heel-lance Premature Infant Pain Profile score","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"0.5 mL of 24% sucrose versus 0.5 mL sterile water","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"2 minutes before lance; acute responses","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata inspected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"59 newborn infants randomized; 44 included in primary EEG analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Neonatal sensory and nociceptive endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Twenty sucrose and 24 water infants in primary EEG analysis. Different pain-related readouts are not interchangeable. Null EEG/reflex results are not universal clinical guidance; no opioid receptor mechanism was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"59 newborn infants randomized; 44 included in primary EEG analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Oral sucrose lowered the composite PIPP score after heel lance compared with water in the neonatal randomized trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. (2010). https://pubmed.ncbi.nlm.nih.gov/20817247/ DOI: 10.1016/S0140-6736(10)61303-7","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral solution before clinically required heel lance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Heel-lance behavioral score, EEG and spinal reflex","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cde5fa41-0b2c-5a22-8739-efa90a79bef2","evidence_kind":"source_excerpt","locator":"Lines 475-485","start_line":475,"end_line":485,"excerpt":"## sucrose-neonatal-pipp\nOral sucrose lowered the composite PIPP score after heel lance compared with water in the neonatal randomized trial.\nModel/species: 59 newborn infants randomized; 44 included in primary EEG analysis\nTissue: Heel-lance behavioral score, EEG and spinal reflex\nExposure: 0.5 mL of 24% sucrose versus 0.5 mL sterile water\nRoute: Oral solution before clinically required heel lance\nDuration: 2 minutes before lance; acute responses\nExposure scope: Neonatal sensory and nociceptive endpoints\nLimits: Twenty sucrose and 24 water infants in primary EEG analysis. Different pain-related readouts are not interchangeable. Null EEG/reflex results are not universal clinical guidance; no opioid receptor mechanism was tested.\nReference: Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial. (2010). https://pubmed.ncbi.nlm.nih.gov/20817247/ DOI: 10.1016/S0140-6736(10)61303-7\nAccess: Primary full-text methods/results and metadata inspected.","model_system":"59 newborn infants randomized; 44 included in primary EEG analysis","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8e24ddf4-84ee-57b4-9fd8-093547432ece","stable_key":"import-c932089b-ebc9-5f39-b2e5-84af74f9f6d0","title":"Sucrose: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text.","file_path":"","sha256":"5e68ccbade7a80fc03778495756f0eeeeba5038cd10d5bef8e33cb1e93e4b044","revision_id":"6edb8ffc-11c5-5cd9-852c-85adb71165a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}