Component
Human modafinil plasma exposure
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Food delayed modafinil peak concentration by about one hour without reducing overall exposure.
Experimental context and source evidence
- evidence_access
- Official label description, pharmacology, pharmacokinetics, indications, interactions and relevant warnings checked.
- experimental_contrast
- {"intervention": "Fed oral modafinil", "comparator": "Fasted oral modafinil", "endpoint": "Food delayed modafinil peak concentration by about one hour without reducing overall exposure.", "effect_direction": "mixed", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Human oral pharmacokinetics in official product label; time to peak and AUC are different measures.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
- plain_language
- Food delayed modafinil peak concentration by about one hour without reducing overall exposure.
- primary_references
- PROVIGIL U.S. prescribing information | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3b8d1c32-dac9-50e6-e063-6394a90aa5a5
- source_locator
- Reviewed reference lines 21-21; exact primary location described in quoted passage where extracted.
Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 21–21
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human oral pharmacokinetics in official product label; time to peak and AUC are different measures. · Recorded from source · Recorded from source
Food can delay peak concentration by about an hour without reducing overall exposure. Metabolism includes hydrolytic deamidation to modafinil acid and S-oxidation to modafinil sulfone; these major metabolites do not appear to explain central arousal. CYP involvement in metabolism and effects on other drugs' CYP-mediated clearance are separate questions. [Official pharmacokinetics](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3b8d1c32-dac9-50e6-e063-6394a90aa5a5)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.