Component
Human MAPT R406W tau variant
Species, preparation, dose and limitations are retained on linked claims.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Annonacin exposure produced greater tau accumulation, phosphorylation and redistribution in R406W-MAPT transgenic mice than in mice with endogenous mouse tau.
Experimental context and source evidence
- dose
- Experimental annonacin exposure
- duration
- Study interval specified in the primary article
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- R406W-MAPT transgenic and non-transgenic mice
- limitations
- Gene-environment interaction in a transgenic model does not establish penetrance or dose-response in humans.
- nutrient_topic
- Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Graviola / Annona muricata
- organism
- R406W-MAPT transgenic and non-transgenic mice
- plain_language
- Annonacin exposure produced greater tau accumulation, phosphorylation and redistribution in R406W-MAPT transgenic mice than in mice with endogenous mouse tau.
- primary_references
- Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. (2014). https://pubmed.ncbi.nlm.nih.gov/24389273/ DOI: 10.1016/j.expneurol.2013.12.017
- route
- In vivo mouse exposure
- tissue
- Tau abundance, phosphorylation, localization and proteasomal activity
Graviola (Annona muricata): mechanism of action and interactions (2026-09-20) · lines 66–75
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · R406W-MAPT transgenic and non-transgenic mice · source_derived_draft · unverified_draft
## graviola-r406w-synergy Annonacin exposure produced greater tau accumulation, phosphorylation and redistribution in R406W-MAPT transgenic mice than in mice with endogenous mouse tau. Model/species: R406W-MAPT transgenic and non-transgenic mice Tissue/system: Tau abundance, phosphorylation, localization and proteasomal activity Exposure: Experimental annonacin exposure Route: In vivo mouse exposure Duration: Study interval specified in the primary article Limits: Gene-environment interaction in a transgenic model does not establish penetrance or dose-response in humans. Primary reference: Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. (2014). https://pubmed.ncbi.nlm.nih.gov/24389273/ DOI: 10.1016/j.expneurol.2013.12.017 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
Where it participates (unsigned role)
Twelve months of the analyzed soursop juice increased somatodendritic phosphorylated-tau-positive neurons, most strongly in R406W-MAPT mice and less in wild-type-tau or non-transgenic mice.
Experimental context and source evidence
- dose
- Commercial soursop juice as drinking fluid
- duration
- 12 months
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Non-transgenic, human-wild-type-MAPT and R406W-MAPT mice
- limitations
- The multi-constituent juice and transgenic susceptibility prevent assignment to annonacin alone or direct prediction of human risk magnitude.
- nutrient_topic
- Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Graviola / Annona muricata
- organism
- Non-transgenic, human-wild-type-MAPT and R406W-MAPT mice
- plain_language
- Twelve months of the analyzed soursop juice increased somatodendritic phosphorylated-tau-positive neurons, most strongly in R406W-MAPT mice and less in wild-type-tau or non-transgenic mice.
- primary_references
- Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and MAPT transgenic mice. (2016). https://pubmed.ncbi.nlm.nih.gov/27569447/ DOI: 10.1111/jnc.13835
- route
- Oral
- tissue
- Regional brain phospho-tau histology
Graviola (Annona muricata): mechanism of action and interactions (2026-09-20) · lines 22–31
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Non-transgenic, human-wild-type-MAPT and R406W-MAPT mice · source_derived_draft · unverified_draft
## graviola-juice-tau Twelve months of the analyzed soursop juice increased somatodendritic phosphorylated-tau-positive neurons, most strongly in R406W-MAPT mice and less in wild-type-tau or non-transgenic mice. Model/species: Non-transgenic, human-wild-type-MAPT and R406W-MAPT mice Tissue/system: Regional brain phospho-tau histology Exposure: Commercial soursop juice as drinking fluid Route: Oral Duration: 12 months Limits: The multi-constituent juice and transgenic susceptibility prevent assignment to annonacin alone or direct prediction of human risk magnitude. Primary reference: Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and MAPT transgenic mice. (2016). https://pubmed.ncbi.nlm.nih.gov/27569447/ DOI: 10.1111/jnc.13835 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.