{"id":"88a693db-c6f7-5426-b94a-4895f0e5c223","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-juice-tau","predicate":"increases","statement":"Twelve months of the analyzed soursop juice increased somatodendritic phosphorylated-tau-positive neurons, most strongly in R406W-MAPT mice and less in wild-type-tau or non-transgenic mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"afae15e7-fac7-5c68-9d73-3196cd9c2736","mechanism_event_label":"Twelve months of the analyzed soursop juice increased somatodendritic phosphorylated-tau-positive neurons, most strongly in R406W-MAPT mice and less in wild-type-tau or non-transgenic mice.","subject":{"id":"a80086e7-d7cd-5487-b9ab-7ece7e008c12","slug":"commercial-soursop-juice-2016","display_name":"Commercial soursop juice used in the 2016 chronic mouse study","entity_type_key":"botanical"},"object":{"id":"74edb4db-4c2c-5038-bece-c48962133933","slug":"mouse-somatodendritic-phosphorylated-tau","display_name":"Somatodendritic phosphorylated tau in mouse brain","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"afae15e7-fac7-5c68-9d73-3196cd9c2736","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-juice-tau-event","event_type":"observed_relationship","label":"Twelve months of the analyzed soursop juice increased somatodendritic phosphorylated-tau-positive neurons, most strongly in R406W-MAPT mice and less in wild-type-tau or non-transgenic mice.","description":"Twelve months of the analyzed soursop juice increased somatodendritic phosphorylated-tau-positive neurons, most strongly in R406W-MAPT mice and less in wild-type-tau or non-transgenic mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a80086e7-d7cd-5487-b9ab-7ece7e008c12","slug":"commercial-soursop-juice-2016","display_name":"Commercial soursop juice used in the 2016 chronic mouse study","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"74edb4db-4c2c-5038-bece-c48962133933","slug":"mouse-somatodendritic-phosphorylated-tau","display_name":"Somatodendritic phosphorylated tau in mouse brain","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f7dd9991-bf06-59a8-8e76-92518a2a7afc","slug":"human-mapt-r406w","display_name":"Human MAPT R406W tau variant","entity_type_key":"protein_state"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Commercial soursop juice as drinking fluid","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"12 months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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(2016). https://pubmed.ncbi.nlm.nih.gov/27569447/ DOI: 10.1111/jnc.13835","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Regional brain phospho-tau histology","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"612e14f5-cffe-5f45-afef-ce4639d3b5fd","evidence_kind":"source_excerpt","locator":"Lines 22-31","start_line":22,"end_line":31,"excerpt":"## graviola-juice-tau\nTwelve months of the analyzed soursop juice increased somatodendritic phosphorylated-tau-positive neurons, most strongly in R406W-MAPT mice and less in wild-type-tau or non-transgenic mice.\nModel/species: Non-transgenic, human-wild-type-MAPT and R406W-MAPT mice\nTissue/system: Regional brain phospho-tau histology\nExposure: Commercial soursop juice as drinking fluid\nRoute: Oral\nDuration: 12 months\nLimits: The multi-constituent juice and transgenic susceptibility prevent assignment to annonacin alone or direct prediction of human risk magnitude.\nPrimary reference: Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and MAPT transgenic mice. (2016). https://pubmed.ncbi.nlm.nih.gov/27569447/ DOI: 10.1111/jnc.13835\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Non-transgenic, human-wild-type-MAPT and R406W-MAPT mice","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dde73deb-4328-5cc7-aa41-04b7d845f4fa","stable_key":"import-cea4b417-bb71-5d5d-8fe1-4e175aca750c","title":"Graviola (Annona muricata): mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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