Component
Patient-reported lymphedema symptoms
Patient-reported lymphedema symptoms. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Moderate/large reported benefit occurred in 15% on coumarin versus 10% on placebo (P=0.19).
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/coumarin-research/9929524.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b", "start_char": 0, "end_char": 1579, "text_sha256": "6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b"}
- experimental_model
- Randomized placebo-controlled crossover replication trial
- exposure
- Coumarin 200 mg twice daily versus placebo, six months each
- limitations
- Specific disease population and pharmacological exposure; liver-test incidence cannot be extrapolated to food doses.
- nutrient_topic
- Coumarin research collection; topical membership is not evidence of a direct dietary effect. · Coumarin
- organism
- Human
- plain_language
- Patient reports did not show a significant benefit.
- primary_references
- [coumarin-p9929524] Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. (1999). https://pubmed.ncbi.nlm.nih.gov/9929524/ DOI: 10.1056/nejm199902043400503
- tissue_or_cell_type
- 140 women with chronic arm lymphedema after breast cancer treatment
Coumarin: metabolism, signaling and nutrient connections (2026-09-17) · lines 774–785
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled crossover replication trial · source_derived_draft · unverified_draft
### coumarin-symptoms-null Moderate/large reported benefit occurred in 15% on coumarin versus 10% on placebo (P=0.19). Condition category: normal nutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Patient reports did not show a significant benefit. organism: Human tissue_or_cell_type: 140 women with chronic arm lymphedema after breast cancer treatment experimental_model: Randomized placebo-controlled crossover replication trial limitations: Specific disease population and pharmacological exposure; liver-test incidence cannot be extrapolated to food doses. exposure: Coumarin 200 mg twice daily versus placebo, six months each evidence_span: {"source_cache": "artifacts/coumarin-research/9929524.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b", "start_char": 0, "end_char": 1579, "text_sha256": "6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b"} [coumarin-p9929524] Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. (1999). https://pubmed.ncbi.nlm.nih.gov/9929524/ DOI: 10.1056/nejm199902043400503
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.