{"id":"5ed2470a-99bd-5937-a4e2-5569179d27cb","stable_key":"f812c44f-d0fd-5f01-ba2c-748c0794fcfb:coumarin-symptoms-null","predicate":"does_not_improve_in_trial","statement":"Moderate/large reported benefit occurred in 15% on coumarin versus 10% on placebo (P=0.19).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0e549026-d5eb-5770-9c5e-d5e41b567002","mechanism_event_label":"Patient reports did not show a significant benefit.","subject":{"id":"9fd9b93a-fdfd-5e09-92d3-0495bff41391","slug":"coumarin","display_name":"Coumarin","entity_type_key":"small_molecule"},"object":{"id":"8b3b9f5e-dc35-5bc1-b383-9ad9ea834edc","slug":"human-lymphedema-symptoms","display_name":"Patient-reported lymphedema symptoms","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0e549026-d5eb-5770-9c5e-d5e41b567002","stable_key":"f812c44f-d0fd-5f01-ba2c-748c0794fcfb:coumarin-symptoms-null-event","event_type":"observed_intervention","label":"Patient reports did not show a significant benefit.","description":"Moderate/large reported benefit occurred in 15% on coumarin versus 10% on placebo (P=0.19).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9fd9b93a-fdfd-5e09-92d3-0495bff41391","slug":"coumarin","display_name":"Coumarin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8b3b9f5e-dc35-5bc1-b383-9ad9ea834edc","slug":"human-lymphedema-symptoms","display_name":"Patient-reported lymphedema symptoms","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coumarin-research/9929524.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b\", \"start_char\": 0, \"end_char\": 1579, \"text_sha256\": \"6d6d4760bdd321dda87f82927c5dfcc7120ed963c101d799473ed53ff4c7764b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled crossover replication trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Coumarin 200 mg twice daily versus placebo, six months each","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Specific disease population and pharmacological exposure; liver-test incidence cannot be extrapolated to food doses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coumarin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coumarin","display_name":"Coumarin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Patient reports did not show a significant benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coumarin-p9929524] Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. 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