Component
ISCU knockdown in human cells
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
ISCU depletion attenuated iron-chelation-induced ISR activation.
Experimental context and source evidence
- access_level
- selected_indexed_full_text_passages
- dose
- Unresolved; not inferred from another panel
- duration
- 72-hour siRNA reported; exact supplementary exposure schedule unresolved
- endpoint
- ATF4/ISR immunoblot readout
- evidence_cache
- artifacts/discovery-research/round2-sources/iscu-counterevidence-search.json; SHA256 91e6dd454b1fdecf0cf4d29d2579bf1eba148109e446059f91ea966f8bf0de21
- experimental_model
- Human cultured cells; precise supplementary-panel cell assignment unresolved
- exposure
- Iron chelation; panel-specific agent and concentration unresolved
- limitations
- Selected primary Results and figure legends accessed through indexed text. Supplements were not independently inspected. These results constrain a hypothesis; they do not test SLC25A39 loss or establish its bypass. Exact iron sensor and transporter substrate remain unresolved.
- organism
- Human
- primary_locator
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10329284/ Results discussing Figure S6B/C
- primary_references
- https://doi.org/10.1016/j.molcel.2023.05.031
Requirements for iron-triggered DELE1 signaling · lines 48–59
Primary study 10.1016/j.molcel.2023.05.031; targeted counterevidence curation, 2026-09-20. · supports · Human cultured cells; precise supplementary-panel cell assignment unresolved · source_derived_draft · unverified_draft
ISCU depletion attenuated iron-chelation-induced ISR activation. primary_references: https://doi.org/10.1016/j.molcel.2023.05.031 primary_locator: https://pmc.ncbi.nlm.nih.gov/articles/PMC10329284/ Results discussing Figure S6B/C evidence_cache: artifacts/discovery-research/round2-sources/iscu-counterevidence-search.json; SHA256 91e6dd454b1fdecf0cf4d29d2579bf1eba148109e446059f91ea966f8bf0de21 access_level: selected_indexed_full_text_passages organism: Human experimental_model: Human cultured cells; precise supplementary-panel cell assignment unresolved duration: 72-hour siRNA reported; exact supplementary exposure schedule unresolved exposure: Iron chelation; panel-specific agent and concentration unresolved dose: Unresolved; not inferred from another panel endpoint: ATF4/ISR immunoblot readout limitations: Selected primary Results and figure legends accessed through indexed text. Supplements were not independently inspected. These results constrain a hypothesis; they do not test SLC25A39 loss or establish its bypass. Exact iron sensor and transporter substrate remain unresolved.
Complete structured claim and evidenceISCU depletion attenuated DELE1 stabilization during iron chelation.
Experimental context and source evidence
- access_level
- selected_indexed_full_text_passages
- dose
- Unresolved; not inferred from another panel
- duration
- 72-hour siRNA reported; exact supplementary exposure schedule unresolved
- endpoint
- DELE1 protein stability immunoblot readout
- evidence_cache
- artifacts/discovery-research/round2-sources/iscu-counterevidence-search.json; SHA256 91e6dd454b1fdecf0cf4d29d2579bf1eba148109e446059f91ea966f8bf0de21
- experimental_model
- Human cultured cells; precise supplementary-panel cell assignment unresolved
- exposure
- Iron chelation; panel-specific agent and concentration unresolved
- limitations
- Selected primary Results and figure legends accessed through indexed text. Supplements were not independently inspected. These results constrain a hypothesis; they do not test SLC25A39 loss or establish its bypass. Exact iron sensor and transporter substrate remain unresolved.
- organism
- Human
- primary_locator
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10329284/ Results discussing Figure S6B/C
- primary_references
- https://doi.org/10.1016/j.molcel.2023.05.031
Requirements for iron-triggered DELE1 signaling · lines 62–73
Primary study 10.1016/j.molcel.2023.05.031; targeted counterevidence curation, 2026-09-20. · supports · Human cultured cells; precise supplementary-panel cell assignment unresolved · source_derived_draft · unverified_draft
ISCU depletion attenuated DELE1 stabilization during iron chelation. primary_references: https://doi.org/10.1016/j.molcel.2023.05.031 primary_locator: https://pmc.ncbi.nlm.nih.gov/articles/PMC10329284/ Results discussing Figure S6B/C evidence_cache: artifacts/discovery-research/round2-sources/iscu-counterevidence-search.json; SHA256 91e6dd454b1fdecf0cf4d29d2579bf1eba148109e446059f91ea966f8bf0de21 access_level: selected_indexed_full_text_passages organism: Human experimental_model: Human cultured cells; precise supplementary-panel cell assignment unresolved duration: 72-hour siRNA reported; exact supplementary exposure schedule unresolved exposure: Iron chelation; panel-specific agent and concentration unresolved dose: Unresolved; not inferred from another panel endpoint: DELE1 protein stability immunoblot readout limitations: Selected primary Results and figure legends accessed through indexed text. Supplements were not independently inspected. These results constrain a hypothesis; they do not test SLC25A39 loss or establish its bypass. Exact iron sensor and transporter substrate remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.