Component

Human isolated hair-follicle shaft elongation

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. SA increased shaft elongation in isolated human follicles.

    Shikimic acid → Human isolated hair-follicle shaft elongation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.
    experimental_contrast
    {"intervention": "SA", "comparator": "Vehicle", "endpoint": "SA increased shaft elongation in isolated human follicles.", "effect_direction": "increase", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Ex-vivo human follicles; 1/10 µM SA, 12-day culture.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Isolated tissue, not clinical oral or topical human hair regrowth.
    plain_language
    SA increased shaft elongation in isolated human follicles.
    primary_references
    Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle. | 2019 | DOI 10.1038/s41598-019-53612-5 | PMID 31740717 | https://pubmed.ncbi.nlm.nih.gov/31740717/ | https://doi.org/10.1038/s41598-019-53612-5 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6861222/
    source_locator
    Reviewed reference lines 75-75; exact primary location described in quoted passage where extracted.

    Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 75–75

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Ex-vivo human follicles; 1/10 µM SA, 12-day culture. · source_derived_draft · unverified_draft

    **Hair-follicle findings include human tissue, not a human treatment trial.** In isolated human hair follicles, 1 or 10 µM shikimic acid increased shaft elongation during 12-day culture. Dermal papilla cells showed higher MTT readouts, and 1 µM exposure increased MYC, HGF, KGF and VEGF transcripts at 24 h and p38/CREB phosphorylation at 15 min. Transcript increases are not proof of increased secreted growth-factor flux. Mannose-receptor staining establishes receptor presence, not that this receptor was necessary for the response. Topical 10–100 mM exposure also affected anagen-related measurements in mice; neither system establishes oral human hair regrowth. [Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle.](https://pubmed.ncbi.nlm.nih.gov/31740717/)
    Complete structured claim and evidence

  2. Mannose-receptor staining was present in the hair-follicle system, but necessity for the SA response was not established.

    The macrophage mannose receptor → Human isolated hair-follicle shaft elongation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.
    experimental_model
    Human follicle immunostaining; unsigned contextual association.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    No direct receptor-binding or receptor-necessity edge asserted.
    plain_language
    Mannose-receptor staining was present in the hair-follicle system, but necessity for the SA response was not established.
    primary_references
    Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle. | 2019 | DOI 10.1038/s41598-019-53612-5 | PMID 31740717 | https://pubmed.ncbi.nlm.nih.gov/31740717/ | https://doi.org/10.1038/s41598-019-53612-5 | https://pmc.ncbi.nlm.nih.gov/articles/PMC6861222/
    source_locator
    Reviewed reference lines 75-75; exact primary location described in quoted passage where extracted.

    Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 75–75

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Human follicle immunostaining; unsigned contextual association. · source_derived_draft · unverified_draft

    **Hair-follicle findings include human tissue, not a human treatment trial.** In isolated human hair follicles, 1 or 10 µM shikimic acid increased shaft elongation during 12-day culture. Dermal papilla cells showed higher MTT readouts, and 1 µM exposure increased MYC, HGF, KGF and VEGF transcripts at 24 h and p38/CREB phosphorylation at 15 min. Transcript increases are not proof of increased secreted growth-factor flux. Mannose-receptor staining establishes receptor presence, not that this receptor was necessary for the response. Topical 10–100 mM exposure also affected anagen-related measurements in mice; neither system establishes oral human hair regrowth. [Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle.](https://pubmed.ncbi.nlm.nih.gov/31740717/)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.