{"id":"0409dd9e-8cdc-5715-b1ab-31723d484372","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:hair-receptor-context","predicate":"reported_relationship","statement":"Mannose-receptor staining was present in the hair-follicle system, but necessity for the SA response was not established.","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"e21a0012-9467-538b-875e-60c2c1bb3b2b","mechanism_event_label":"Mannose-receptor staining was present in the hair-follicle system, but necessity for the SA response was not established.","subject":{"id":"78496a78-f03c-56a0-87ab-6f9aaafba38f","slug":"mannose-receptor","display_name":"The macrophage mannose receptor","entity_type_key":"protein"},"object":{"id":"079c91da-cd27-5016-8858-b77666c2ac08","slug":"human-hair-shaft-elongation","display_name":"Human isolated hair-follicle shaft elongation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e21a0012-9467-538b-875e-60c2c1bb3b2b","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:hair-receptor-context-event","event_type":"experimental_observation","label":"Mannose-receptor staining was present in the hair-follicle system, but necessity for the SA response was not established.","description":"**Hair-follicle findings include human tissue, not a human treatment trial.** In isolated human hair follicles, 1 or 10 µM shikimic acid increased shaft elongation during 12-day culture. Dermal papilla cells showed higher MTT readouts, and 1 µM exposure increased MYC, HGF, KGF and VEGF transcripts at 24 h and p38/CREB phosphorylation at 15 min. Transcript increases are not proof of increased secreted growth-factor flux. Mannose-receptor staining establishes receptor presence, not that this receptor was necessary for the response. Topical 10–100 mM exposure also affected anagen-related measurements in mice; neither system establishes oral human hair regrowth. [Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle.](https://pubmed.ncbi.nlm.nih.gov/31740717/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"78496a78-f03c-56a0-87ab-6f9aaafba38f","slug":"mannose-receptor","display_name":"The macrophage mannose receptor","entity_type_key":"protein"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"079c91da-cd27-5016-8858-b77666c2ac08","slug":"human-hair-shaft-elongation","display_name":"Human isolated hair-follicle shaft elongation","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text retrieved; relevant methods/results/figures reviewed. 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Dermal papilla cells showed higher MTT readouts, and 1 µM exposure increased MYC, HGF, KGF and VEGF transcripts at 24 h and p38/CREB phosphorylation at 15 min. Transcript increases are not proof of increased secreted growth-factor flux. Mannose-receptor staining establishes receptor presence, not that this receptor was necessary for the response. Topical 10–100 mM exposure also affected anagen-related measurements in mice; neither system establishes oral human hair regrowth. [Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle.](https://pubmed.ncbi.nlm.nih.gov/31740717/)","model_system":"Human follicle immunostaining; unsigned contextual association.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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