Component

HDL cholesterol in garlic intervention trials

HDL cholesterol in garlic intervention trials. Interpret through the linked study species, preparation, exposure and measured endpoint.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The aged-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.

    Aged garlic extract intervention in Gardner 2007 → HDL cholesterol in garlic intervention trials source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.
    experimental_contrast
    {"intervention": "aged-garlic-gardner-2007", "comparator": "Placebo", "endpoint": "The aged-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    192 adults randomized across four arms; clove-equivalent products six days/week for six months.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Preparation-specific human null; not an inference that isolated allicin inhibits or fails to inhibit every cholesterol enzyme.
    plain_language
    The aged-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.
    primary_references
    Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. | 2007 | DOI 10.1001/archinte.167.4.346 | PMID 17325296 | https://pubmed.ncbi.nlm.nih.gov/17325296/ | https://doi.org/10.1001/archinte.167.4.346
    source_locator
    Reviewed reference lines 91-91; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 91–91

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 192 adults randomized across four arms; clove-equivalent products six days/week for six months. · source_derived_draft · unverified_draft

    **Cholesterol null.** Gardner randomized 192 adults with moderately elevated LDL cholesterol to raw garlic, garlic powder, aged garlic extract, or placebo for six months. Products equivalent to roughly a four-gram clove were used six days per week and chemically monitored. None significantly improved LDL, HDL, triglycerides, or the total-cholesterol/HDL ratio. This substantial null result should remain visible beside biochemical enzyme findings. It neither disproves every possible formulation nor proves that all positive trials were publication bias. [Gardner 2007](https://pubmed.ncbi.nlm.nih.gov/17325296/)
    Complete structured claim and evidence

  2. The garlic-powder-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.

    Garlic powder intervention in Gardner 2007 → HDL cholesterol in garlic intervention trials source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.
    experimental_contrast
    {"intervention": "garlic-powder-gardner-2007", "comparator": "Placebo", "endpoint": "The garlic-powder-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    192 adults randomized across four arms; clove-equivalent products six days/week for six months.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Preparation-specific human null; not an inference that isolated allicin inhibits or fails to inhibit every cholesterol enzyme.
    plain_language
    The garlic-powder-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.
    primary_references
    Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. | 2007 | DOI 10.1001/archinte.167.4.346 | PMID 17325296 | https://pubmed.ncbi.nlm.nih.gov/17325296/ | https://doi.org/10.1001/archinte.167.4.346
    source_locator
    Reviewed reference lines 91-91; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 91–91

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 192 adults randomized across four arms; clove-equivalent products six days/week for six months. · source_derived_draft · unverified_draft

    **Cholesterol null.** Gardner randomized 192 adults with moderately elevated LDL cholesterol to raw garlic, garlic powder, aged garlic extract, or placebo for six months. Products equivalent to roughly a four-gram clove were used six days per week and chemically monitored. None significantly improved LDL, HDL, triglycerides, or the total-cholesterol/HDL ratio. This substantial null result should remain visible beside biochemical enzyme findings. It neither disproves every possible formulation nor proves that all positive trials were publication bias. [Gardner 2007](https://pubmed.ncbi.nlm.nih.gov/17325296/)
    Complete structured claim and evidence

  3. The raw-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.

    Raw garlic intervention in Gardner 2007 → HDL cholesterol in garlic intervention trials source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.
    experimental_contrast
    {"intervention": "raw-garlic-gardner-2007", "comparator": "Placebo", "endpoint": "The raw-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    192 adults randomized across four arms; clove-equivalent products six days/week for six months.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Preparation-specific human null; not an inference that isolated allicin inhibits or fails to inhibit every cholesterol enzyme.
    plain_language
    The raw-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.
    primary_references
    Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. | 2007 | DOI 10.1001/archinte.167.4.346 | PMID 17325296 | https://pubmed.ncbi.nlm.nih.gov/17325296/ | https://doi.org/10.1001/archinte.167.4.346
    source_locator
    Reviewed reference lines 91-91; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 91–91

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 192 adults randomized across four arms; clove-equivalent products six days/week for six months. · source_derived_draft · unverified_draft

    **Cholesterol null.** Gardner randomized 192 adults with moderately elevated LDL cholesterol to raw garlic, garlic powder, aged garlic extract, or placebo for six months. Products equivalent to roughly a four-gram clove were used six days per week and chemically monitored. None significantly improved LDL, HDL, triglycerides, or the total-cholesterol/HDL ratio. This substantial null result should remain visible beside biochemical enzyme findings. It neither disproves every possible formulation nor proves that all positive trials were publication bias. [Gardner 2007](https://pubmed.ncbi.nlm.nih.gov/17325296/)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.