{"id":"c0460ab2-d4a2-53f8-9f8d-36e9280304a9","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:gardner-aged-garlic-gardner-2007-human-garlic-trial-hdl","predicate":"no_detected_change_in_recorded_experiment","statement":"The aged-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"eb656df5-903a-5a6f-b21b-d384c96c2545","mechanism_event_label":"The aged-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.","subject":{"id":"1d3fc68a-8c69-5b05-917d-e17fa460d0ec","slug":"aged-garlic-gardner-2007","display_name":"Aged garlic extract intervention in Gardner 2007","entity_type_key":"botanical"},"object":{"id":"dd9362a2-81b8-58ca-8608-4834194eb894","slug":"human-garlic-trial-hdl","display_name":"HDL cholesterol in garlic intervention trials","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"eb656df5-903a-5a6f-b21b-d384c96c2545","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:gardner-aged-garlic-gardner-2007-human-garlic-trial-hdl-event","event_type":"experimental_observation","label":"The aged-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.","description":"**Cholesterol null.** Gardner randomized 192 adults with moderately elevated LDL cholesterol to raw garlic, garlic powder, aged garlic extract, or placebo for six months. Products equivalent to roughly a four-gram clove were used six days per week and chemically monitored. None significantly improved LDL, HDL, triglycerides, or the total-cholesterol/HDL ratio. This substantial null result should remain visible beside biochemical enzyme findings. It neither disproves every possible formulation nor proves that all positive trials were publication bias. [Gardner 2007](https://pubmed.ncbi.nlm.nih.gov/17325296/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1d3fc68a-8c69-5b05-917d-e17fa460d0ec","slug":"aged-garlic-gardner-2007","display_name":"Aged garlic extract intervention in Gardner 2007","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"aged-garlic-gardner-2007","sequence_order":0,"notes":""},{"entity":{"id":"dd9362a2-81b8-58ca-8608-4834194eb894","slug":"human-garlic-trial-hdl","display_name":"HDL cholesterol in garlic intervention trials","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"aged-garlic-gardner-2007\", \"comparator\": \"Placebo\", \"endpoint\": \"The aged-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"192 adults randomized across four arms; clove-equivalent products six days/week for six months.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preparation-specific human null; not an inference that isolated allicin inhibits or fails to inhibit every cholesterol enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The aged-garlic-gardner-2007 intervention did not significantly improve HDL cholesterol in the six-month randomized trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. | 2007 | DOI 10.1001/archinte.167.4.346 | PMID 17325296 | https://pubmed.ncbi.nlm.nih.gov/17325296/ | https://doi.org/10.1001/archinte.167.4.346","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 91-91; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ecf964e2-6499-5870-a1df-6bf3e88b0e04","evidence_kind":"source_excerpt","locator":"Lines 91-91","start_line":91,"end_line":91,"excerpt":"**Cholesterol null.** Gardner randomized 192 adults with moderately elevated LDL cholesterol to raw garlic, garlic powder, aged garlic extract, or placebo for six months. Products equivalent to roughly a four-gram clove were used six days per week and chemically monitored. None significantly improved LDL, HDL, triglycerides, or the total-cholesterol/HDL ratio. This substantial null result should remain visible beside biochemical enzyme findings. It neither disproves every possible formulation nor proves that all positive trials were publication bias. [Gardner 2007](https://pubmed.ncbi.nlm.nih.gov/17325296/)","model_system":"192 adults randomized across four arms; clove-equivalent products six days/week for six months.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"10820a6b-594a-547d-97f9-906ab4cc1d6e","stable_key":"import-c836a883-ac18-5eb2-9971-2f0b542feba8","title":"Allicin: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"2475d3eb681100a0a34577a47b7cba5b251df866fbd6ce795122ccabee360018","revision_id":"590df96d-2ed1-5763-b04c-bf0e096e603c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}