Component
Fisetin plus interval resistance/aerobic exercise
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The 12-week four-arm trial reported the largest asprosin and MCP-1 reductions in men receiving exercise plus 200 mg/day fisetin.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- 60 randomized; intention-to-treat analysis, 44 per-protocol; IRCT20120129008863N14.
- limitations
- Largest change alone does not establish synergy. Abstract BMI inequality is inconsistent with full-text BMI >30 eligibility.
- nutrient_topic
- Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Fisetin
- plain_language
- A combined intervention changed metabolic-inflammatory markers.
- primary_references
- The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41683255/ · DOI 10.3390/nu18030433
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19) · lines 520–526
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · 60 randomized; intention-to-treat analysis, 44 per-protocol; IRCT20120129008863N14. · source_derived_draft · unverified_draft
## fisetin-obesity-adipokines A combined intervention changed metabolic-inflammatory markers. The 12-week four-arm trial reported the largest asprosin and MCP-1 reductions in men receiving exercise plus 200 mg/day fisetin. Model: 60 randomized; intention-to-treat analysis, 44 per-protocol; IRCT20120129008863N14. Limitations: Largest change alone does not establish synergy. Abstract BMI inequality is inconsistent with full-text BMI >30 eligibility. Evidence access: Primary full text The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41683255/ · DOI 10.3390/nu18030433
Complete structured claim and evidenceThe related exercise/fisetin report found maresin-1 increases in the training-placebo and training-fisetin arms.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- 44 completers; same IRCT20120129008863N14 registration as the adipokine paper.
- limitations
- Linked report, not independent replication; circulating maresin does not demonstrate its biosynthetic mechanism.
- nutrient_topic
- Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Fisetin
- plain_language
- The exercise response cannot be assigned entirely to fisetin.
- primary_references
- 12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42218768/ · DOI 10.1080/15502783.2026.2679718
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19) · lines 528–534
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · 44 completers; same IRCT20120129008863N14 registration as the adipokine paper. · source_derived_draft · unverified_draft
## fisetin-obesity-maresin The exercise response cannot be assigned entirely to fisetin. The related exercise/fisetin report found maresin-1 increases in the training-placebo and training-fisetin arms. Model: 44 completers; same IRCT20120129008863N14 registration as the adipokine paper. Limitations: Linked report, not independent replication; circulating maresin does not demonstrate its biosynthetic mechanism. Evidence access: Primary full text 12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42218768/ · DOI 10.1080/15502783.2026.2679718
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.