{"id":"68956956-29db-5c43-8a46-17d29a0a02d6","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-obesity-adipokines","predicate":"reduces","statement":"The 12-week four-arm trial reported the largest asprosin and MCP-1 reductions in men receiving exercise plus 200 mg/day fisetin.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dab9fb9f-d490-5a1a-8586-0ae907fa19d7","mechanism_event_label":"A combined intervention changed metabolic-inflammatory markers.","subject":{"id":"7c9441e1-1bf0-593f-bd43-92e99729558e","slug":"human-fisetin-exercise-combination","display_name":"Fisetin plus interval resistance/aerobic exercise","entity_type_key":"cellular_process"},"object":{"id":"b29c8b31-485f-5796-9eb3-c0c3b8a95b08","slug":"human-fisetin-trial-asprosin-mcp1","display_name":"Asprosin and MCP-1 in the fisetin/exercise trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dab9fb9f-d490-5a1a-8586-0ae907fa19d7","stable_key":"74ef5bba-ee14-531c-b1bf-d1f297c56bb6:fisetin-obesity-adipokines-event","event_type":"observed_relationship","label":"A combined intervention changed metabolic-inflammatory markers.","description":"The 12-week four-arm trial reported the largest asprosin and MCP-1 reductions in men receiving exercise plus 200 mg/day fisetin.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7c9441e1-1bf0-593f-bd43-92e99729558e","slug":"human-fisetin-exercise-combination","display_name":"Fisetin plus interval resistance/aerobic exercise","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b29c8b31-485f-5796-9eb3-c0c3b8a95b08","slug":"human-fisetin-trial-asprosin-mcp1","display_name":"Asprosin and MCP-1 in the fisetin/exercise trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"dee05061-c3f3-5226-8054-dd58b76a585d","slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"60 randomized; intention-to-treat analysis, 44 per-protocol; IRCT20120129008863N14.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Largest change alone does not establish synergy. Abstract BMI inequality is inconsistent with full-text BMI >30 eligibility.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fisetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fisetin","display_name":"Fisetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A combined intervention changed metabolic-inflammatory markers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41683255/ · DOI 10.3390/nu18030433","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"38631ea4-1a95-5c40-b92b-93f925a0a170","evidence_kind":"source_excerpt","locator":"Lines 520-526","start_line":520,"end_line":526,"excerpt":"## fisetin-obesity-adipokines\nA combined intervention changed metabolic-inflammatory markers.\nThe 12-week four-arm trial reported the largest asprosin and MCP-1 reductions in men receiving exercise plus 200 mg/day fisetin.\nModel: 60 randomized; intention-to-treat analysis, 44 per-protocol; IRCT20120129008863N14.\nLimitations: Largest change alone does not establish synergy. Abstract BMI inequality is inconsistent with full-text BMI >30 eligibility.\nEvidence access: Primary full text\nThe Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41683255/ · DOI 10.3390/nu18030433","model_system":"60 randomized; intention-to-treat analysis, 44 per-protocol; IRCT20120129008863N14.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1108bfff-6504-5152-a51f-ff3d7c27c282","stable_key":"import-74ef5bba-ee14-531c-b1bf-d1f297c56bb6","title":"Fisetin: metabolism, cell-state responses and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c30e0764cd34bd062cfcbfaf32357ef29dfda30e7d4153c545178140f5054e09","revision_id":"40ff52c0-f4b9-5820-8abb-ff002c6364a4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}