Component
Association of human dp-ucMGP with renal function
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
dp-ucMGP interpretation is associated with kidney function in the transplant cohort.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_access
- Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.
- experimental_model
- Kidney-transplant observational cohort; biomarker context.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Not source-specific vitamin K, proof of microbial depletion, or an isolated renal-clearance mechanism.
- plain_language
- dp-ucMGP interpretation is associated with kidney function in the transplant cohort.
- primary_references
- Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies. | 2021 | DOI 10.3390/nu13093069 | PMID 34578950 | https://pubmed.ncbi.nlm.nih.gov/34578950/ | https://doi.org/10.3390/nu13093069 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8467091/
- source_locator
- Reviewed reference lines 33-33; exact primary location described in quoted passage where extracted.
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026) · lines 33–33
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Kidney-transplant observational cohort; biomarker context. · Recorded from source · Recorded from source
**Kidney function complicates dp-ucMGP interpretation.** The kidney-transplant study associated lower estimated GFR with higher circulating dp-ucMGP, and recorded a large fall after transplantation. This is a biomarker-context observation, not an assay identifying the microbial origin of vitamin K or isolating renal clearance as the only explanation. A related published comment exists and causal interpretation remains open. A correlation among glyphosate exposure, fecal menaquinones and dp-ucMGP would not by itself establish the entire proposed causal chain. [Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies.](https://pubmed.ncbi.nlm.nih.gov/34578950/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.