{"id":"c99c9735-72a2-5261-aab2-58b551244d1c","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:kidney-marker","predicate":"reported_relationship","statement":"dp-ucMGP interpretation is associated with kidney function in the transplant cohort.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"d36ab8eb-6eaf-523a-b1d3-c82d56b1d4e4","mechanism_event_label":"dp-ucMGP interpretation is associated with kidney function in the transplant cohort.","subject":{"id":"b5cf80a2-c423-5ff5-806e-fa37ddaf7303","slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"},"object":{"id":"5109ff3e-8221-5a26-953d-b8959e6578e7","slug":"human-dpucmgp-renal-association","display_name":"Association of human dp-ucMGP with renal function","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d36ab8eb-6eaf-523a-b1d3-c82d56b1d4e4","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:kidney-marker-event","event_type":"experimental_observation","label":"dp-ucMGP interpretation is associated with kidney function in the transplant cohort.","description":"**Kidney function complicates dp-ucMGP interpretation.** The kidney-transplant study associated lower estimated GFR with higher circulating dp-ucMGP, and recorded a large fall after transplantation. This is a biomarker-context observation, not an assay identifying the microbial origin of vitamin K or isolating renal clearance as the only explanation. A related published comment exists and causal interpretation remains open. A correlation among glyphosate exposure, fecal menaquinones and dp-ucMGP would not by itself establish the entire proposed causal chain. [Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies.](https://pubmed.ncbi.nlm.nih.gov/34578950/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b5cf80a2-c423-5ff5-806e-fa37ddaf7303","slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"5109ff3e-8221-5a26-953d-b8959e6578e7","slug":"human-dpucmgp-renal-association","display_name":"Association of human dp-ucMGP with renal function","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text retrieved; relevant methods/results/figures reviewed. Selective extraction, not raw-data reanalysis or exhaustive supplemental extraction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Kidney-transplant observational cohort; biomarker context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not source-specific vitamin K, proof of microbial depletion, or an isolated renal-clearance mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"dp-ucMGP interpretation is associated with kidney function in the transplant cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies. | 2021 | DOI 10.3390/nu13093069 | PMID 34578950 | https://pubmed.ncbi.nlm.nih.gov/34578950/ | https://doi.org/10.3390/nu13093069 | https://pmc.ncbi.nlm.nih.gov/articles/PMC8467091/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 33-33; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"bf743617-b0a5-58d3-8f0d-05504f051b60","evidence_kind":"source_excerpt","locator":"Lines 33-33","start_line":33,"end_line":33,"excerpt":"**Kidney function complicates dp-ucMGP interpretation.** The kidney-transplant study associated lower estimated GFR with higher circulating dp-ucMGP, and recorded a large fall after transplantation. This is a biomarker-context observation, not an assay identifying the microbial origin of vitamin K or isolating renal clearance as the only explanation. A related published comment exists and causal interpretation remains open. A correlation among glyphosate exposure, fecal menaquinones and dp-ucMGP would not by itself establish the entire proposed causal chain. [Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies.](https://pubmed.ncbi.nlm.nih.gov/34578950/)","model_system":"Kidney-transplant observational cohort; biomarker context.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e6ae59de-0369-5c2f-8262-57d91302671c","stable_key":"import-31b1baa4-4113-5541-b9e7-fe44a5253a07","title":"Shikimic acid: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"95b1f9e9577661312d67f36e156d2e49326b207f296c1c0e801a5b007fd8e283","revision_id":"cd3237f1-131a-557d-84b5-7543259807b0","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}