Component
Human transdiaphragmatic pressure during phrenic-nerve stimulation
Human transdiaphragmatic pressure during phrenic-nerve stimulation. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
After serum phosphorus rose from 0.55 to 1.33 mmol/L, mean stimulated transdiaphragmatic pressure increased from 9.75 to 17.25 cm H2O.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/phosphorus-research/3860734.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf061281363419c0833fd3b160950e7f4c1a57ebeef46f3b73a0ad30f3b7f7e1", "start_char": 0, "end_char": 1400, "text_sha256": "cf061281363419c0833fd3b160950e7f4c1a57ebeef46f3b73a0ad30f3b7f7e1"}
- experimental_model
- Before/after phosphate correction with phrenic-nerve stimulation
- exposure
- Historical protocol: 10 mmol phosphorus as KH2PO4 infused over four hours
- limitations
- Small uncontrolled physiological experiment; potassium was also administered. Not a general infusion recommendation or proof of one intracellular mediator.
- nutrient_topic
- Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
- organism
- Human
- plain_language
- Correcting the low phosphate measurement accompanied stronger diaphragm contractions in these patients.
- primary_references
- [phosphorus-p3860734] Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. (1985). https://pubmed.ncbi.nlm.nih.gov/3860734/ DOI: 10.1056/nejm198508153130705
- tissue_or_cell_type
- Eight ventilated patients with acute respiratory failure
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1050–1061
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Before/after phosphate correction with phrenic-nerve stimulation · source_derived_draft · unverified_draft
### phosphorus-diaphragm-rescue After serum phosphorus rose from 0.55 to 1.33 mmol/L, mean stimulated transdiaphragmatic pressure increased from 9.75 to 17.25 cm H2O. Condition category: biomarker_context nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: Correcting the low phosphate measurement accompanied stronger diaphragm contractions in these patients. organism: Human tissue_or_cell_type: Eight ventilated patients with acute respiratory failure experimental_model: Before/after phosphate correction with phrenic-nerve stimulation limitations: Small uncontrolled physiological experiment; potassium was also administered. Not a general infusion recommendation or proof of one intracellular mediator. exposure: Historical protocol: 10 mmol phosphorus as KH2PO4 infused over four hours evidence_span: {"source_cache": "artifacts/phosphorus-research/3860734.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf061281363419c0833fd3b160950e7f4c1a57ebeef46f3b73a0ad30f3b7f7e1", "start_char": 0, "end_char": 1400, "text_sha256": "cf061281363419c0833fd3b160950e7f4c1a57ebeef46f3b73a0ad30f3b7f7e1"} [phosphorus-p3860734] Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. (1985). https://pubmed.ncbi.nlm.nih.gov/3860734/ DOI: 10.1056/nejm198508153130705
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.