{"id":"92c4f4f5-5c73-5119-ae1b-91770ffb72c3","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-diaphragm-rescue","predicate":"increases","statement":"After serum phosphorus rose from 0.55 to 1.33 mmol/L, mean stimulated transdiaphragmatic pressure increased from 9.75 to 17.25 cm H2O.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5b15cce2-c8a5-573c-8784-cd0fcc32bea8","mechanism_event_label":"Correcting the low phosphate measurement accompanied stronger diaphragm contractions in these patients.","subject":{"id":"a7c7981d-bf19-5e76-a2e4-aeb3769c202d","slug":"phosphate-repletion-study-interventions","display_name":"Study-specific phosphate repletion interventions","entity_type_key":"chemical_species"},"object":{"id":"27d5c228-1481-5bf2-add7-701564d1dae9","slug":"human-diaphragm-stimulated-pressure","display_name":"Human transdiaphragmatic pressure during phrenic-nerve stimulation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5b15cce2-c8a5-573c-8784-cd0fcc32bea8","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-diaphragm-rescue-event","event_type":"observed_intervention","label":"Correcting the low phosphate measurement accompanied stronger diaphragm contractions in these patients.","description":"After serum phosphorus rose from 0.55 to 1.33 mmol/L, mean stimulated transdiaphragmatic pressure increased from 9.75 to 17.25 cm H2O.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"coadministered_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ee63fe8e-92f3-552f-8049-a5f1fa1e1523","slug":"phosphate-ion","display_name":"Inorganic phosphate (Pi; protonation depends on pH)","entity_type_key":"ion"},"role":"repleted_ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a7c7981d-bf19-5e76-a2e4-aeb3769c202d","slug":"phosphate-repletion-study-interventions","display_name":"Study-specific phosphate repletion interventions","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"27d5c228-1481-5bf2-add7-701564d1dae9","slug":"human-diaphragm-stimulated-pressure","display_name":"Human transdiaphragmatic pressure during phrenic-nerve stimulation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/3860734.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"cf061281363419c0833fd3b160950e7f4c1a57ebeef46f3b73a0ad30f3b7f7e1\", \"start_char\": 0, \"end_char\": 1400, \"text_sha256\": \"cf061281363419c0833fd3b160950e7f4c1a57ebeef46f3b73a0ad30f3b7f7e1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Before/after phosphate correction with phrenic-nerve stimulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Historical protocol: 10 mmol phosphorus as KH2PO4 infused over four hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small uncontrolled physiological experiment; potassium was also administered. 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Not a general infusion recommendation or proof of one intracellular mediator.\nexposure: Historical protocol: 10 mmol phosphorus as KH2PO4 infused over four hours\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/3860734.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"cf061281363419c0833fd3b160950e7f4c1a57ebeef46f3b73a0ad30f3b7f7e1\", \"start_char\": 0, \"end_char\": 1400, \"text_sha256\": \"cf061281363419c0833fd3b160950e7f4c1a57ebeef46f3b73a0ad30f3b7f7e1\"}\n[phosphorus-p3860734] Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. 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