Component
Human CXCR1/CXCR2 chemokine receptors
Species, preparation, dose and limitations are retained on linked claims.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Bromelain removed CXCR1/CXCR2 from human neutrophils and reduced IL-8-directed migration by about 40%.
Experimental context and source evidence
- dose
- In-vitro bromelain treatment; in-vivo preparation specified in the primary study
- duration
- Acute
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Isolated human neutrophils; three murine inflammation models
- limitations
- The effect was stimulus-selective and does not imply global suppression of neutrophil migration or human clinical efficacy.
- nutrient_topic
- Bromelain chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Bromelain
- organism
- Isolated human neutrophils; three murine inflammation models
- plain_language
- Bromelain removed CXCR1/CXCR2 from human neutrophils and reduced IL-8-directed migration by about 40%.
- primary_references
- Bromelain treatment decreases neutrophil migration to sites of inflammation. (2008). https://pubmed.ncbi.nlm.nih.gov/18482869/ DOI: 10.1016/j.clim.2008.02.015
- route
- In vitro and in vivo
- tissue
- Chemokine-receptor surface expression and chemotaxis
Bromelain: mechanism of action and interactions (2026-09-20) · lines 33–42
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Isolated human neutrophils; three murine inflammation models · source_derived_draft · unverified_draft
## bromelain-neutrophil-cxcr Bromelain removed CXCR1/CXCR2 from human neutrophils and reduced IL-8-directed migration by about 40%. Model/species: Isolated human neutrophils; three murine inflammation models Tissue/system: Chemokine-receptor surface expression and chemotaxis Exposure: In-vitro bromelain treatment; in-vivo preparation specified in the primary study Route: In vitro and in vivo Duration: Acute Limits: The effect was stimulus-selective and does not imply global suppression of neutrophil migration or human clinical efficacy. Primary reference: Bromelain treatment decreases neutrophil migration to sites of inflammation. (2008). https://pubmed.ncbi.nlm.nih.gov/18482869/ DOI: 10.1016/j.clim.2008.02.015 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.