Component

Human carnosinase 1 / CNDP1

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Recombinant human CNDP1 hydrolyzed carnosine, with a reported Km of 1.2 mM.

    Human carnosinase 1 / CNDP1 → L-Carnosine / beta-alanyl-L-histidine source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Purified human protein expressed in CHO cells.
    limitations
    Kinetic constant is not a plasma threshold.
    nutrient_topic
    Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit. · L-Carnosine / beta-alanyl-L-histidine
    plain_language
    A separate enzyme breaks the peptide down.
    primary_references
    Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12473676/ · DOI 10.1074/jbc.M209764200

    Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19) · lines 44–50

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Purified human protein expressed in CHO cells. · source_derived_draft · unverified_draft

    ## carnosine-cndp1-hydrolysis A separate enzyme breaks the peptide down. Recombinant human CNDP1 hydrolyzed carnosine, with a reported Km of 1.2 mM. Model: Purified human protein expressed in CHO cells. Limitations: Kinetic constant is not a plasma threshold. Evidence access: Primary abstract Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12473676/ · DOI 10.1074/jbc.M209764200
    Complete structured claim and evidence

  2. Intact carnosine became detectable in sampled plasma when ex vivo blood carnosinase activity was inhibited.

    Human carnosinase 1 / CNDP1 → Human measured plasma intact carnosine source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Human blood-sample handling experiment.
    limitations
    A negative untreated plasma assay cannot prove no absorption occurred.
    nutrient_topic
    Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit. · L-Carnosine / beta-alanyl-L-histidine
    plain_language
    Breakdown after blood collection can hide the signal.
    primary_references
    Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1910085/ · DOI 10.1113/jphysiol.1991.sp018673
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19) · lines 84–90

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human blood-sample handling experiment. · source_derived_draft · unverified_draft

    ## carnosine-sample-hydrolysis Breakdown after blood collection can hide the signal. Intact carnosine became detectable in sampled plasma when ex vivo blood carnosinase activity was inhibited. Model: Human blood-sample handling experiment. Limitations: A negative untreated plasma assay cannot prove no absorption occurred. Evidence access: Primary abstract Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1910085/ · DOI 10.1113/jphysiol.1991.sp018673
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards