Component
Human carotid atherosclerotic stenosis
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The carnitine arm in the same trial had greater progression of carotid stenosis than placebo, reported as a 9.3% difference; total and LDL cholesterol also increased.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Same 157-participant randomized trial; secondary endpoints.
- limitations
- Different endpoints are not a contradiction; the study does not isolate TMAO as the mediator.
- nutrient_topic
- L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit. · L-Carnitine
- plain_language
- A different vascular endpoint showed a concerning signal.
- primary_references
- Progression of atherosclerosis with carnitine supplementation: a randomized controlled trial in the metabolic syndrome. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35366920/ · DOI 10.1186/s12986-022-00661-9
L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19) · lines 434–440
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Same 157-participant randomized trial; secondary endpoints. · source_derived_draft · unverified_draft
## l-carnitine-human-stenosis A different vascular endpoint showed a concerning signal. The carnitine arm in the same trial had greater progression of carotid stenosis than placebo, reported as a 9.3% difference; total and LDL cholesterol also increased. Model: Same 157-participant randomized trial; secondary endpoints. Limitations: Different endpoints are not a contradiction; the study does not isolate TMAO as the mediator. Evidence access: Primary abstract Progression of atherosclerosis with carnitine supplementation: a randomized controlled trial in the metabolic syndrome. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35366920/ · DOI 10.1186/s12986-022-00661-9
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.