{"id":"c6c4a0a5-98a4-5f97-9a77-e8fdce23c6f7","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-human-stenosis","predicate":"increases","statement":"The carnitine arm in the same trial had greater progression of carotid stenosis than placebo, reported as a 9.3% difference; total and LDL cholesterol also increased.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3411bbf5-e453-54e0-90a3-94cfcf78ae5b","mechanism_event_label":"A different vascular endpoint showed a concerning signal.","subject":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"object":{"id":"398f474d-f4bc-5848-bdc1-d114f6f0fc6b","slug":"human-carotid-stenosis","display_name":"Human carotid atherosclerotic stenosis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3411bbf5-e453-54e0-90a3-94cfcf78ae5b","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-human-stenosis-event","event_type":"observed_relationship","label":"A different vascular endpoint showed a concerning signal.","description":"The carnitine arm in the same trial had greater progression of carotid stenosis than placebo, reported as a 9.3% difference; total and LDL cholesterol also increased.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"398f474d-f4bc-5848-bdc1-d114f6f0fc6b","slug":"human-carotid-stenosis","display_name":"Human carotid atherosclerotic stenosis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same 157-participant randomized trial; secondary endpoints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different endpoints are not a contradiction; the study does not isolate TMAO as the mediator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A different vascular endpoint showed a concerning signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Progression of atherosclerosis with carnitine supplementation: a randomized controlled trial in the metabolic syndrome. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35366920/ · DOI 10.1186/s12986-022-00661-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"99428d62-da3e-5095-977c-15fc9c73595a","evidence_kind":"source_excerpt","locator":"Lines 434-440","start_line":434,"end_line":440,"excerpt":"## l-carnitine-human-stenosis\nA different vascular endpoint showed a concerning signal.\nThe carnitine arm in the same trial had greater progression of carotid stenosis than placebo, reported as a 9.3% difference; total and LDL cholesterol also increased.\nModel: Same 157-participant randomized trial; secondary endpoints.\nLimitations: Different endpoints are not a contradiction; the study does not isolate TMAO as the mediator.\nEvidence access: Primary abstract\nProgression of atherosclerosis with carnitine supplementation: a randomized controlled trial in the metabolic syndrome. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35366920/ · DOI 10.1186/s12986-022-00661-9","model_system":"Same 157-participant randomized trial; secondary endpoints.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2c9c42b-806a-55e2-abde-b0320ea94704","stable_key":"import-6cdb37aa-8998-5ea8-829d-4f995caf98fc","title":"L-Carnitine: synthesis, acyl-group transport, fuel selection and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"6fcd86d9d02babb48b2ce658d506afe84580ad4b242f93f11f742d934fa5b361","revision_id":"398e3b52-45bc-52e3-891e-656c19ca674f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}